Home Builder Developer - Interior Renovation and Design

New Jersey, United States,- Verified Market Research sheds light on the market scope, potential, and performance perspective of the Countertop Platelet Incubator Market by carrying out an extensive market analysis. Pivotal market aspects like market trends, the shift in customer preferences, fluctuating consumption, cost volatility, the product range available in the market, growth rate, drivers and constraints, financial standing, and challenges existing in the market are comprehensively evaluated to deduce their impact on the growth of the market in the coming years. The report also gives an industry-wide competitive analysis, highlighting the different market segments, individual market share of leading players, and the contemporary market scenario and the most vital elements to study while assessing the Countertop Platelet Incubator market.

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Leading Countertop Platelet Incubator manufacturers/companies operating at both regional and global levels:

The report also inspects the financial standing of the leading companies, which includes gross profit, revenue generation, sales volume, sales revenue, manufacturing cost, individual growth rate, and other financial ratios.

Industrial Analysis:

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In Market Segmentation by Types of Countertop Platelet Incubator, the report covers-

Bytype1

In Market Segmentation by Applications of the Countertop Platelet Incubator, the report covers the following uses-

Byapplication1

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Sales Forecast:

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Countertop Platelet Incubator Market Growth By Manufacturers, Countries, Types And Application, End Users And Forecast To 2026 - 3rd Watch News

Organizing the kitchen can feel intimidating, especially if you have maxed out on all available kitchen cabinets and shelves. While most of us want our kitchen to look spick and span by keeping the counter tops empty, it still remains the most cluttered part of the kitchen. Kitchen organizers like plate and dish racks, overhead shelves and sink organizers are a few tools that can maximize your space and make it much more organized. Racks with designated slots for plates, spoons and other kitchen essentials furnish the countertop with an aesthetic vertical storage solution and make it orderly and clean. Here are our recommendations of kitchen organization racks you can buy online: Crafted from a durable,heavy-duty plastic, that is environmentally safe, this kitchen rack has a hollow structure with a diversion tray at the bottom that makes it easy to drain water after washing utensils. The basket also features a designated slot for chopsticks and spoons, making it convenient for users to organize their utensils. This rack is perfect for storing all kinds of utensils that need to go for washing. '; var randomNumber = Math.random(); var isIndia = (window.geoinfo && window.geoinfo.CountryCode === 'IN') && (window.location.href.indexOf('outsideindia') === -1 ); //console.log(isIndia && randomNumber Designed with thick wires of high grade stainless steel in order to withstand heavy load, this rack would be an excellent addition to the space next to your kitchen sink. Alternatively, this steel rack can also be used on a table for storing folders and files. The rack also features an anti-scratch cap that protects surfaces from getting spoiled. This rack can be used on the counter top, inside a cabinet as well as on a table. Adding portable shelves to your cabinets is an excellent method for increasing storage capacity of the kitchen. This steel rack is sturdy and sleek and can be used for multiple purposes on both the countertop and the kitchen cabinet. This steel rack is expandable and stackable, making it ideal for cabinets, open shelves, sliding drawers and even the fridge. The rack also comes with an anti-skid cap that prevents the stand from slipping. This kitchen rack would be excellent for storing all spice jars together. This shelf is made of full metal frame with chrome plating, which ensures sturdiness and durability. The size of this steel rack is 40 x 19.5 x 36 cm, which makes it versatile enough to be used for multiple other purposes like storing toiletries or make up products. In the kitchen, this rack will provide vertical storage space that can be used to store jars and containers that are usually left on the kitchen counter. This kitchen rack would provide a sleek storage that can be placed over a microwave oven. The boxy appliance definitely takes away a major chunk of the counter space and this rack provides a hack to make that occupied area more useful. The rack is crafted in plastic and grill and is specially designed for providing storage above a microwave oven.DISCLAIMER: The Times of India's journalists were not involved in the production of this article.

Read the rest here:
Declutter your kitchen with these countertop kitchen organizers - Times of India

East county residents are ready to move forward as the county continues to work on reopening.

Many residents have spent the past three months confined at home and quarantine has served to highlight every flaw and outdated fixture that appeared fine before March. With the county lifting restrictions, many residents are looking to update their homes, add a home workspace or make things more accessible for elderly loved ones.

James Carey of Carey Bros. Remodeling is a third-generation licensed contractor. His company has over 40 years experience in the East Bay and this year he said, there has been a significant spike in homeowners looking to add an attached bedroom or accessory dwelling unit (ADU) for an adult child or aging parent.

The reason for that is the aging population, and with the COVID thing the kids are not at school, they are living at home, so that is the straw that broke the camels back, Carey explained. So people are saying we need this extra space and we need an ADU. Lets go ahead and build that space that we have been talking about.

Carey added that the lack of affordable housing in California is another driver of the ADUs, and local and state government has made it easier to build one by reducing the distance a dwelling can be placed in relation to the property line, fast-tracking the permitting processes and lowering permit fees.

Carey said many of his jobs include the request to make things accessible by widening doors, adding ramps, and installing grab bars and easy-to-operate doorknobs and faucet fixtures. He noted these do not have to look institutional, but come in many attractive designs and finishes.

Carey said one thing homeowners are not loving right now are sunken living spaces. In the 70s and 80s, said Carey, it was very vogue to step down into the family room. But now, many of his customers are asking him to bring those floor levels up thereby removing a barrier for people who may struggle with steps.

Joe Lindsey, owner of Brentwoods White Rhino Construction, said he firmly believes the pandemic has affected the remodeling and construction business.

A lot of people, instead of wanting an entire remodel, they want to do a reface, Lindsey said. Instead of spending the money to do a whole bathroom, they just want to change out the shower door, add new fixtures and paint the cupboards I think its because they are uncertain about the future and the economy.

Despite uncertainties about what might lie ahead, Lindsey said his business began picking up in mid-June. Some big trends he sees are painted, two-toned cabinets; large subway tiles; and pocket doors. Lindsey recommended homeowners installing pocket doors to create space in small rooms invest in a steel framed door that wont warp and require readjustment over time.

One thing his customers are getting rid of is bathtubs.

A lot of people are getting rid of the bathtub and just doing a shower, he said. I recommend they keep one, for resale value, but a lot of people dont want any.

Carey Bros. Remodeling is located at 2624 Verne Roberts Circle, Suite D107, in Antioch. For more information, call 877-734-6404 or visit http://www.careybros.com.

Continued here:
Remodeling in a COVID-19 world | Living - thepress.net

From the Greater Orlando Builders Association

The Greater Orlando Builders Association (GOBA), the authority, educator and promoter of the housing and building industry, announces new dates for the 67thannual Parade of Homes Orlando.

Central Floridians are invited to safely experience 65+ of the best of the best homes throughout Orange, Seminole and Osceola County and surrounding areas during the FREE, self-guided tourSat., July 18 through Sun., July 26, 2020.

We are pleased to announce the new dates for this highly anticipated event featuring Central Floridas most inspiring homes. Whether youre looking for a new home, wish to re-imagine your current home or are searching for a spark of inspiration, the 67th Annual Parade of Homes Orlando is open to everyone interested and enthused by stylish home design, said Rick Caccavello, Parade of Homes Orlando chairman and president of Central Kitchen & Bath.

Parade of Homes Orlando showcasesCentral Floridas most inspiring homebuilders and designers. Discover innovations in homebuilding, architectural design, energy efficiency, smart homes, outdoor living, interior style, remodeling and pool design.

For more photos, information and directions to this Apopka home visit

While things may be a little different this year, guests can safely visit 65+ entries ranging from new communities, new homes, whole house renovations and specialty remodeling. All participants have extra safety practices in place in compliance with all local, state and healthcare organizationguidelineswith Parade attendee comfort in mind for the continued prevention of coronavirus (COVID-19).

Complimentary guidebooks are available at Parade of HomesOrlando entrylocations and Trustco Banks throughoutgreater OrlandoMonday Saturday and daily at select Sherwin-Williams stores beginning July 13.

Search for entries and plan your Parade route by visitingwww.ParadeOfHomesOrlando.com. The website is your go-to resource to find home and builder information, individual participant daily hours, guidebook pick-up locations, driving directions and more. Plus, enter to win the kitchen appliance and cabinetry package valued at $10,000 presented by Central Kitchen & Bath and Aggressive Appliances.

This years Showcase Home, Casa de los Reyes by Turning Leaf Custom Homes. Located in the heart of Winter Park, this sprawling 5,764 total square-foot home features a custom Mediterranean design with five bedrooms, five and a half baths, media room, study room, gated courtyard front entry, hand-selected concrete barrel roof tiles, custom pool design and much more. With numerous green-building elements, this custom development is Home Innovation National Green Building Standard (NGBS) Registeredand has received gold level certification.

For more information, visitParadeofHomesOrlando.com.

Greater Orlando Builders Association (GOBA) is the authority, educator and promoter of the housing and building industry representing more than 700 members and 25,000+ employees. Since 1953, GOBA has served the construction industry in Seminole, Orange and Osceola counties. The intention is to foster an environment within the association and within our neighborhoods to create opportunities for building relationships, businesses and communities while balancing economic, social and environmental needs of our members and communities served.For more information, visitwww.greaterorlandoba.comand @BuildOrlando on social media platforms.

Read more:
Apopka house featured at 67th Annual Parade of Homes in July - The Apopka Voice

Kandi Burruss' husband, Todd Tucker, showedanother interesting side of himself as he gave a tour of his daughter Blaze's room, which he designed and decorated from scratch.

There are many ways to show and prove one's love for a child. Being there and going out of your way to make them comfortable are some of the common ones, but designing one's child's room is another heartwarming way of showing love.

"Real Housewives of Atlanta" star Kandi Burruss' daughter Blaze is getting an overwhelming dose of love from her father, Todd Tucker, as he designed and decorated her room.

Todd Tuckershared a video of the room on his YouTube channel,"Todd Tucker TV." The clip was a tour of Blaze's room and the remodeling that went into creating a beautiful sleeping area for her.

In the video, Todd, who worean all-black costume while sporting his full beards, carried seven months old Blaze in his hands as he gave viewers a chance to see the gray-themed room he put together. Heexpressed that:

"I decorated. I designed. I picked the colors, the furniture, the pillows, the accents. I did the bathroom... all for my little baby girl right here, Blaze."

He started by showing the marquee letters which spelled "Blaze."He attested that the reason he used the marquee letters and the light was that he believed every child needed to see their name in lights before seeing them in "light."

Blaze alsocame along for the tour,dressed in a pink ruffled jumper and was all smiles as her dad pointed out to the things he had done. He highlighted that not everything in the room was newly bought as he preferred to use old stuff if they still functioned.

Todd then showed the gray-themed room walls and pointed out that certain things like the baby cot, the drawer, and the rocker had been handed down to Blaze by her elder brother, Ace.

Another exciting highlight of the room was the bed, which had a roll-out bed. On the bed Todd said: "As Blaze gets older and has friends come over I don't need to spend too much money on it later."

The bathroom was also in shades of gray and white, and the wall had a mosaic feel to it. Blaze's closet perhaps stole the show as it was filled with various colorful outfits befitting of her style.

Kandi Burruss madea brief appearance in the eleven-minute videoand explained that when it came to designing, Todd had the upper hand. While she loved the style, she added that the wall could use a little design later on.

Kandi and Toddwelcomed Blazeon November 22, 2019, via a surrogate. The couple opted for surrogacy due to the complications Kandi faced with her previous pregnancies.

The ever-smiling Blaze entered the family andendeared herself to everyone's hearts,and even the world, with hermillion-dollar smile, which earned her a modeling gig.

Aside from redecorating rooms, Todd is also invested in his community. He has promised and urged others to use what they have to make a change in others' lives.

Link:
Kandi Burruss' Husband Todd Tucker Shows off His Daughter Blaze's Room Which He Put Together Himself (Video) - AmoMama

Fridays and Saturdays are typically the busiest summer days of the week. When the Fourth of July and very warm weather falls on a weekend, it can be especially busy.

July 3 Officers were called to a local hotel. A man told them that he had met a woman at a gas station who agreed to accompany him to his room. When he awoke the next morning, she was gone as was twelve dollars in cash and his 9 mm handgun.

July 3 A young woman called the police to report that a few months ago her boyfriend threatened to shoot up a school. When the officer asked her for her address, she supplied it. Grand Rapids, Michigan.

July 3 A man reported the theft of a window air conditioner. He explained that the ten-year-old unit was mounted on a vacant house he is remodeling. I guess we know the temperatures must really be hot when thieves are out stealing air conditioners.

July 3 A deputy was flagged down by a motorist who reported a man was drunk and crazy in the middle of Fifth Street at Third Ave NE. When officers and the deputy arrived, they found a man who was obviously drunk, standing in the middle of the street shouting obscenities at passing motorists. Officers tried to calm him and escort him to the curb. It didnt work. When he shouted an obscenity aimed toward a female officer he was handcuffed and marched off to jail.

July 3 Hospital Security reported that a woman who was high on drugs and went running out of the hospital emergency room, yelling and screaming. They chased her through the parking lot and finally got her stopped at Golf Course Road. The woman was shouting incoherently and had lacerations on her arms. Officers managed to get her back to the emergency room.

July 4 A woman asked for police assistance stating that she had let some people park a camper in her yard and now they are refusing to pay her and refusing to leave.

July 4 Officers were called to a house on a report that a man had been assaulted. When they arrived, they found the bloodied homeowner. He claimed that a stranger kicked in his front door, entered his house and began punching him, yelling something about money owed to him. The man then left, returning a few moments later and started kicking the homeowner. He then drove off. Officers spotted the vehicle while en route to the call and they stopped it. They arrested the driver for Assault, Burglary and DWI. He was placed in jail.

July 4 A local hotel called, reporting that a woman had been assaulted by her husband. Investigation revealed that the couple had travelled to Grand Rapids for the weekend to look at some vacation property. That night they got into an argument in their hotel room. The husband head butted and choked the wife who then ran from the room. The husband was arrested and went to jail.

All told, over a three-day period, Grand Rapids Police Officers responded to nearly one-hundred calls.

Go here to read the rest:
Policing the Rapids: Fourth of July responses | Columnists - Herald Review

Why wouldn't the homes people plan to buy, build, or remodel reflect some of the lessons learned during this pandemic? Almost everything else in our world has been affected in some way by this situation.

When your home becomes your office, gym, or your child's school, it is not unexpected that you'd want more room, some dedicated spaces, and some other pertinent or practical changes.

For many Europeans, bidets are not only astandard way of life, many countries require them by law. Here in the U.S. - -not so much. And while they'll never be legislated here, people are coming around to their benefits.

Due to the Great Toilet Paper Shortage of 2020, companies that make and market bidets have seen a boost to their bottom lines. (Sorry, I couldn't resist!)More homebuyers are seeing them as a necessity, along with smart bathroom technology items like touchless toilets.

Something I've never really cared for is the open floor plan that has been a staple of home design for decades. You couldn't watch a home buying or remodeling show on HGTV without the prospective client mentioning that they wanted the "open floor concept". Well now, that may be changing.

Having the capability to self-isolate from other family members became very important over the last 6 months, and thanks to the continuing unknowns of our current crisis, will continue to be so.

Bigger lots are becoming more desirable for the same reason; more space between you and other people. Multi-generational homes are becoming popular due to the fact that people didn't like being separated from lovedones living in senior communities.

Finally, because more people have been avoiding shopping in stores and e-commerce has climbed to new levels,not to mention the fact that porch pirates have been very busy lately, designers are being asked to add safe package drop-off areas to homes.

Source: Livability

View original post here:
COVID-19 Will Change Homes According to Real Estate Experts - KSOO News

An artists rendering shows the new Jefferson Elementary School, which will be built behind the football field at South Middle School. The city codes office issued a nearly $18 million permit for the project last month.(Photo: Provided)

HENDERSON, Ky. -- The Henderson County Board of Education secured a nearly $18 million building permit last month for construction of a new two-story Jefferson Elementary School at 800 S. Alves St., behind the South Middle School football field.

The new Jefferson Elementary will feature 17 classrooms; three kindergarten rooms; a media center; music, computer, art and special education rooms; a gymnasium with a stage; a cafeteria; and offices and related facilities.

The building will accommodate up to 400 students, contain 57,250 square feet and sit on a school system-owned tract covering about eight acres.

In an earlier statement, Superintendent Marganna Stanley said the school will also include learning labs, spaces for STEAM (Science, Technology, Engineering, the Arts and Mathematics) education, an energy-efficient design and a safe learning environment for our students.

Enrollment at the current Jefferson Elementary this past school year was 340 students.

The new school will have its own entrance off Alves Street and its own parking lot.

Additional parking will be added on the campus of South Middle to help alleviate the on-street parking that occurs during school functions and events. That will include a new staff parking lot at the corner of South Alves and Cherry streets that will incorporate a new parent drop-off/pickup zone and a new event parking lot on South Alves near Norris Lane.

Earthwork for the project has begun, and the building is projected to be completed during the 2021-22 school year, according to Steve Steiner, assistant superintendent of administration for Henderson County Schools.

The construction manager for the new Jefferson Elementary will be Codell Construction and the architect is Hafer Design.

The new school will replace the 56-year-old Jefferson Elementary building, which was judged in a 2011 facility evaluation to be in poor condition. Stanley has cited issues ranging from the need to replace the HVAC system, windows and doors to improve energy efficiency as well as learning spaces (that) are chopped up. They are not conducive to 21st century learning by any means.

The new Jefferson will be the third elementary school here bearing that name, following the current school on South Green at Jackson Street, which opened in 1964, and an earlier Jefferson School at the northeast corner of Jefferson and South Elm streets.

The building permit for the school, the biggest issued here in years, brought the total value of new construction authorized last month to nearly $20.8 million.

The other major commercial construction project that got the green light in the city in June was a $1.1 million interior remodeling permit for the Walmart Supercenter store at 1195 Barret Blvd.

There were no commercial or industrial permits issued by the county in June.

Permits for five new single-family residences were issued in June, including three in the city two of which will be Habitat for Humanity of Henderson homes, both on Cumnock Street and two in the county. A permit was also issued for one residential duplex.

Residential construction was developing at a reasonable rate earlier this year, especially out in the county, before the Covid-19 pandemic set in. The county codes office issued 16 permits for new homes during the first four months of the year, but only two since for a total of 18 at mid-year.

The city issued no permits for new houses in April and May. Through the first six months of 2020, it has issued seven.

So halfway through the year, the city and county have issued a total of 25 permits for new single-family homes with an average construction value of $129,960 (excluding the value of land and other non-construction related expenses). New residence permits in the county have an average construction cost of $147,000 compared with $118,267 in the city.

For the first six months of the year, the city and county have issued permits authorizing nearly $28.5 million of construction, obviously dominated by the Jefferson school project.

Here are the permits issued by the city and county last month:

City

Commercial, accessory: Holy Name Parish, 511 Second St., $250,000.

Commercial, new: Gary W. and Brenda Crawford, 1705 S. Green St., $97,000; and Henderson County Board of Education, 800 S. Alves St., $18.0 million.

Commercial, remodel: Walmart Real Estate Business Trust, 1195 Barret Blvd., $1.1 million.

Demolition, single-family residence: Margaret L. Pruitt Estate, 1027 Stewart Ave., $4,290; and Audubon Kids Zone, 1414 Powell St., $3,400.

Residential duplex, new: Gary and Lisa Attebery, 1616 Roosevelt St., $75,000.

Manufactured homes, new: James and Cynthia Lambert, 2820 Sunset Lane, $39,900; and Mark Stefansky, 510 Watson Lane #13, $48,000.

Single-family residential accessory: Jason Messeman, 912 Watson Lane, $8,000; Chelsea M. Mills, 2014 Morning Dove Ct., $2,500; Bradley W. and Priscilla Woosley, 1661 Bruce St., $5,000; Stephen R. (Sr.) and Amy Lynn Brann, 2708 Brettwood Lane, $4,500; Daniel P. and Abbie Boswell Pennaman, 1321 Glengary Way, $2,500; John and Karen Totton, 2361 Green River Road, $10,000; Shannon R. and Danielle Troutman, 101 N. Partridge Lane, $28,000; Marion E. and Lisa G. Gross, 2019 Summer Hill Lane, $4,000; Melissa Burkes, 1303 N. Green St., $3,000; Robert Wayne and Vicki A. McClure, 1809 White Oak Ct., $2,500; Michael V. and Amber C. Chandler, 1250 Alastair Dr., $6,000; Aaron Gregory and Melissa L. Pritchett, 334 S. Main St., $18,000; John F. and Nancy L. Klein, 665 Constanza Dr., $15,000; and Ernest Mays, 1024 Clay St., $1,000.

Single-family residential addition: William I. Markwell, 923 S. Main St., $20,000; and AJ Rentals LLC, 843 Cherokee Dr., $30,000.

Single-family residence,new: Habitat for Humanity of Henderson, 1233 Cumnock St., $115,000; HCM LLC, 1463 Arrow Way, $149,800; and Habitat for Humanity of Henderson, 1535 Cumnock St., $90,000.

Single-family residence, remodel: Mark A. and Donna L. Nally, 1340 Adams Lane, $75,000; Kentucky Apartments LLC, 1914 Powell St., $15,000; and James Martin Coursey Jr. and Carley Monet Haase, 2392 Balmoral Dr., $3,000.

Sign: Eastgate MHP LLC c/o Drew Warner, 1713 Franklin Ave., $800; Brad D. Higginson, 625 S. Main St., $950; Clifton O. Williams, et al, 1228 Second St., $600; Community United Methodist Hospital Inc., 1305 N. Elm St., $44,917 and $4,200 (two permits); Bob J. Vanzant, 2751 U.S. 41-North, $27,000; and Gardenside Center LLC, 2606 Zion Road, $13,565.

Total estimated construction value: $20.2 million.

County

New residence: Thompson Homes, 16246 Kentucky 136-East, $120,000; and Alex and Abbie Walters, 4182 Dr. Floyd Rd., $175,000.

Room addition: Eric and Joy Ries, 8976 Kentucky 1078-South, $20,000; Gregory Perkins, 4026 Kentucky 136-West, $8,000; Kelly Deep, 4346 St Olaf Circle, $32,442; and Glenn Kerr, 1377 Kentucky 416-East, $15,000.

Sign: New Hope Baptist Church, 5514 U.S. 60-East, $35,000.

Manufactured home: James Ambrous, 6711 Crooked Rd., $10,000.

Garages/utility: Dusty Risley, 5271 Kentucky 1299, $20,000; Carl and Christi Honeycutt, 11002 Kentucky 1078-North, $25,000; Jimmy McGann, 6057 Bauern Ct., $45,000; Larry Alexander, 4153 Briscoe Benton Rd., $15,000; and Tim and Cordelia Ann Shelton, 5792 Cairo Hickory Grove Rd, $5,249.

Miscellaneous: Harley Heath, 7134 Airline Rd., $44,900

Total estimated construction value: $570,591.

Read or Share this story: https://www.thegleaner.com/story/news/2020/07/07/18-million-permit-new-jefferson-elementary-among-those-issued-henderson/5392179002/

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$18 million permit for new Jefferson Elementary among those issued in Henderson - The Gleaner

Two years after it first emerged from stealth mode, Flagships Foghorn Therapeutics has nabbed its first Big Pharma partner as Merck signs on to the biotechs vision of drugging the very shape of DNA.

The deal, worth up to $425 million but with the upfront cash undisclosed, comes as Foghorn nears a pivot to a clinical stage biotech. The Cambridge-based company has added nearly 60 staffers from the 25 it had when it first emerged out of Flagship and, CEO Adrian Gottschalk said, they have finally refined the screening technology at the heart of the company, with plans to file their first IND towards the end of the year.

In the last 6 months, actually prior to the conversations with Merck, we had industrialized our ability to interrogate the biology, Gottschalk told Endpoints News.Weve made some very nice progress, really starting from scratch several years ago.

First founded in 2016, Foghorn is one of a spate of recent biotechs that try to treat cancer by targeting how genes are expressed, as opposed to trying to change the genes themselves or inhibit the proteins they code for. Michael Gilmans Arrakis Therapeutics is built, like Foghorn, on drugging DNA regulators called transcription factors and earlier this year got $190 million upfront and several billion in milestones for a deal with Roche. Syros, another Flagship-backed company, attracted considerable buzz several years ago by going after so-called super-enhancers, though they have since struggled to find traction in the clinic. More broadly, the still-juvenile field has yielded few major in-human successes.

Merck has already signaled its belief in the approach, at least in certain manifestations. Last year, they bought up Peloton Theraepeutics and its late-stage, kidney cancer transcription factor drug for $1 billion in cash and another $1 billion in milestones.

Foghorns twist, Gottschalk said, is looking at how these factors interact with these spherical structures on top of DNA, called chromatin remodeling complexes. Basically, human DNA contains billions of genes, not all of which are turned on at any point in time or in any cell. That DNA sits in tightly compacted strands called chromatin at the nucleus at the center of the cell, and one of the ways the body can decide which genes need to be turned on is to open and close those strands.

The molecular thing that determines whether and where genes are turned on is the interaction between those transcription factors that carry instructions and the chromatin remodeling complex that does the opening and closing. Foghorn compares it to air traffic control, the two types of proteins telling the genes where to launch and where not to launch. And Gottschalk cited data that suggest around 25% of cancers can be chalked up in part to those biological controllers getting their signals crossed.

For the last four years, Foghorn has developed a high-throughput screening system to allow their scientists to model both the transcription factors and the remodeling complexes and figure out which molecules can modulate each. Though high-throughput screening is about as common a word in the drug industry these days as pancakes are in the diner industry, Gottschalk said that was no easy feat. The chromatin remodeling complexes are just that complex and they needed to set up a system that could handle proteins as much as ten times as large as the ones most screens handle.

Under the new deal, Merck has essentially licensed one of the factors Foghorn has just begun testing, buying exclusivity on any potential drugs that emerge to target it. Internally, meanwhile, Gottschalk said that after years building their systems, the company is preparing to soon bring a few of its 10 preclinical and unnamed programs into the clinic for several genetically-defined cancers that currently have few good treatment options.

I think this biology has been unexplored and unexploited as drug, and I think the time is right, Gottschalk said.

Continue reading here:
Merck dangles up to $425 million to team with Flagship's Foghorn Therapeutics on drugging the shape of DNA - Endpoints News

This 6,616-square-foot new build on Strait Lane fits the streets reputation for large, elaborately designed homes. The design is open, modern and minimalistic.

Listing agent Janelle Alcantara said the home has a unique design.

This is really dramatically different from any other house thats out there, Alcantara said.

The home was built by architect Doug Guiling, who has worked primarily in commercial architecture but wanted to build a speculative home. This is the second home he has built on Strait Lane. The other is next door.

The home has five bedrooms, five bathrooms and three half-bathrooms. The open concept in the living areas is magnified by large windows and natural light.

Neutral tones flow throughout the home with varying colors of wood throughout.

The living, kitchen and breakfast area are in a large room that is open to the second level. The room overlooks the natural backyard and the pool on the back porch through a wall of windows. A secondary kitchen (or catering kitchen) sits behind a wall in the primary kitchen, making more room for entertaining and preparation. Wood cabinets in the kitchen match the paneling details throughout the living room and on the stairway that leads to the second level.

The grand stairway is accented by a large, round window of glass that looks between the stairs and the living room.

A formal dining area, living area and wine room are also on the first floor.

The primary suite, a first-floor room, overlooks the backyard and porch. It has an attached sitting room with a fireplace and floor-to-ceiling windows.

The remaining four bedrooms are on the second floor, each with their own en suite bathroom. An upstairs living area, study and a play room with patio access add to the homes living space.

Outside, there is a covered pool adjacent to the back patio of the home with a nearby sitting area. The remainder of the back yard is open and has a natural feel.

11468 Strait Lane is listed for $3,695,000 by Janelle Alcantara of Briggs Freeman Sothebys International Realty.

1/12A look at the property at 11468 Strait Lane in Dallas.(Shoot2Sell Photography)

2/12A look at the property at 11468 Strait Lane in Dallas.(Shoot2Sell Photography)

3/12A look at the property at 11468 Strait Lane in Dallas.(Shoot2Sell Photography)

4/12A look at the property at 11468 Strait Lane in Dallas.(Shoot2Sell Photography)

5/12A look at the property at 11468 Strait Lane in Dallas.(Shoot2Sell Photography)

6/12A look at the property at 11468 Strait Lane in Dallas.(Shoot2Sell Photography)

7/12A look at the property at 11468 Strait Lane in Dallas.(Shoot2Sell Photography)

8/12A look at the property at 11468 Strait Lane in Dallas.(Shoot2Sell Photography)

9/12A look at the property at 11468 Strait Lane in Dallas.(Shoot2Sell Photography)

10/12A look at the property at 11468 Strait Lane in Dallas.(Shoot2Sell Photography)

11/12A look at the property at 11468 Strait Lane in Dallas.(Shoot2Sell Photography)

12/12A look at the property at 11468 Strait Lane in Dallas.(Shoot2Sell Photography)

Read more from the original source:
Peek inside this Dallas spec house on Strait Lane and marvel at the modern details - The Dallas Morning News