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    Plumbing the marvels of ‘mRNA’ in creating vaccines, therapeutics – Dorchester Reporter

    - January 20, 2021 by Mr HomeBuilder

    One of Moderna co-founder Derrick Rossis favorite things to say is that there are three keys to life on Earth: DNA makes mRNA makes protein makes life.

    The experimental technology behind Moderna and Pfizers coronavirus vaccines harnesses the power of one of those keys messenger RNA, or mRNA. They are the first medical products to use mRNA in this way, but they certainly wont be the last. A Covid-19 vaccine is just one of the near-infinite possibilities the technology offers, Rossi said.

    Being able to control mRNA would allow scientists to manipulate life in astonishing new ways. It could open the door to new treatments for diseases like cystic fibrosis, cancer, and HIV. Now, bolstered by the apparent success of the Covid vaccine, Rossi said, those other applications may soon come to fruition.

    Within 10 years time, well see probably dozens of mRNA therapeutics. In maybe 15 years time, well see maybe 50 or 60 mRNA therapeutics, he said.

    Before Rossi co-founded Moderna, he was a biologist at Harvard tinkering with mRNA. DNA is often described as the building block of life, but DNA is essentially a database of information cells need to create proteins. RNA is the molecule that actually does the work of creating those proteins.

    For years, Rossi and other scientists tried designing strands of mRNA that would force cells to make specific proteins. But long before this technique created the worlds highest profile vaccines, they failed.

    It totally didnt work, Rossi said. What it looked like to the cell was that the mRNA was a virus. And the cell, like a good soldier, would elicit a very robust antiviral response.

    Every time Rossi tried to insert the mRNA, the cell would either destroy the molecule or kill itself not at all what he wanted. He felt like hed hit a wall. The solution came from another part of the cell and two scientists at the University of Pennsylvania discovered it.

    Katalin Karik, then a junior scientist at UPenn and now a senior vice president at BioNTech, another company that has developed a Covid vaccine, was trying to do the same thing that Rossi was and coming up empty, too. But a colleague of Karik at UPenn, Dr. Drew Weissmansuggested that Karik try using modified chemical letters in her mRNA code.

    By modifying the RNA, it cloaks the RNA. Its like giving it a fake passport, said Timothy Springer, an immunologist at Boston Childrens Hospital and Harvard Medical School. And it worked brilliantly.

    The modified chemical letters disguised the mRNA, making it appear more or less innocent to the cell. When Rossi read about Karik and Weissmans work, he immediately startedincorporating their technique into his own research. In one experiment, he directed cells to create proteins called Yamanaka factors that converted mature cells into stem cells. In another, he injected mice with mRNA encoded for the protein that makes fireflies light up.

    And then you know, an hour later, we put the mice into this machine, and we could see this glowing spot, Rossi said.

    The experiments were working, and now Rossi knew how to control one of the three most fundamental keys to life. He took the new data to Springer, also an accomplished entrepreneur, and asked him to help start a company based on the new technology.

    Springer jumped on board, becoming the companys first investor. They called it Moderna short for modified and RNA. Both still own stock in the company.

    The possibilities were unlimited, Springer said. You know, the RNA can encode for anything. They could be encoding secreted protein or an enzyme in the cell or a vaccine unit, you know, to protect against SARS-CoV-2.

    Over the last decade, Modernaand other companies like BioNTech have been studying modified mRNA technology as a way to develop treatments fora wide variety of diseases including heart failure and chikungunya virus. Other researchers have found ways to use modified mRNA to makeadvancesin anti-aging research.

    And modified mRNA is particularly suited to creating vaccines, Springer said. Thats because while those modified chemical letters allow the molecule to sneak past cellular defenses, the compoundstill looks somewhat suspicious. It doesnt completely sneak by, he said, theres a little bit of interest. Maybe the eyebrows of the immune system perk up.

    The mRNA in a vaccine carries the code for a pathogen protein like the spike protein from the coronavirus. When the cell begins executing the code from the vaccine and manufacturing that protein, the already wary immune system flares into action and produces a particularly strong immune response. That might be one reason why the coronavirus vaccines from Moderna and Pfizer have beenso effectiveso far in clinical trials, Springer said.

    That property, along with others, makes modified mRNA an attractive option for cancer vaccines, said Dr. Cathy Wu, an oncologist at the Dana Farber Cancer Institute. These vaccines train the immune system to attack tumors, but creating them takes a long time and its expensive. Thats a problem for cancer patients.

    If someone has advanced cancer, you cant really wait that long, she said. Being able to build vaccines in a timely fashion is probably whats going to be needed to make this actually work. mRNA vaccines can be made lightning fast. All thats needed to create a new one is rewrite the genetic code in the vaccine. The Covid vaccine took only days to design once researchers had the novel coronaviruss genome. This could also be an advantage if the coronavirus mutates in a way that makes the current vaccines less effective.

    The technology provides a nimble platform that you can switch things up quickly, Wu said.

    Now that the Covid vaccine is being produced on a massive scale, Wu said, that might also help drive down some costs for the technology, as manufacturers find more efficient ways of making the mRNA. The last step remaining for cancer vaccines is to be tested in large clinical studies.

    Thats true of other applications for modified mRNA, too. Wu pointed out that with two mRNA COVID-19 vaccines now in use, billions of dollars are going into the new technology. Other therapeutics arent likely to be too far behind.

    This article was published by WBUR 90.9FM on Jan. 11. WBUR and the Reporter share content through a media partnership.

    Originally posted here:
    Plumbing the marvels of 'mRNA' in creating vaccines, therapeutics - Dorchester Reporter

    Plumbing Fixtures Market (2021-2026) | Potential growth, attractive valuation make it is a long-term investment | Geberit AG, Jacuzzi, Inc – The…

    - January 20, 2021 by Mr HomeBuilder

    Key strategies in the global Plumbing Fixtures market like product developments, partnerships, mergers and acquisitions, etc., analysed in this report. The worth of strategic analysis has been rigorously investigated in conjunction with undisputed market challenges. The Plumbing Fixtures market report delivers conclusion that includes breakdown and data triangulation, consumer needs/customer preference change, research findings, market size estimation, data source. These factors will increase the business overall.

    Why should you invest in Plumbing Fixtures Business?

    If you are aiming to enter the Plumbing Fixtures business, this report is a comprehensive guide that provides crystal clear insights into this niche market. All the major application areas for Plumbing Fixtures are covered in this report and information is given on the important regions of the world where this market is likely to boom during the upcoming years, so that you can plan your strategies to enter this market accordingly. Besides, through this report, you can have a complete grasp of the level of competition you will be facing in this hugely competitive market and if you are an established player in this market already, this report will help you gauge the strategies that your competitors have adopted to stay as business leaders in this market. For new entrants to this market, the voluminous data provided in this report is invaluable.

    Table of Content (TOC)

    Regional Analysis for Plumbing Fixtures Market:

    In conclusion,the Plumbing Fixtures Market report is a reliable source for accessing the research data that is projected to exponentially accelerate your business. The report provides information such as economic scenarios, benefits, limits, trends, market growth rates, and figures. SWOT analysis is also incorporated in the report along with speculation attainability investigation and venture return investigation.

    Talk to our Industry Expert for any quiry and customization@https://www.worldwidemarketreports.com/quiry/459532

    Contact Us:

    Mr. ShahWorldwide Market ReportsSeattle, WA 98154, U.S.Email:sales@worldwidemarketreports.com

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    Plumbing Fixtures Market (2021-2026) | Potential growth, attractive valuation make it is a long-term investment | Geberit AG, Jacuzzi, Inc - The...

    Plumbing Hardware Market Size By Analysis, Key Vendors, Regions, Type and Application, and Forecasts to 2027 – NeighborWebSJ

    - January 20, 2021 by Mr HomeBuilder

    Fort Collins, Colorado: Reports Globe has published the latest study on Plumbing Hardware Market Report Analysis by Size with Future Outlook, Key Players SWOT Analysis and Forecast to 2026. It uses exploratory techniques such as qualitative and quantitative analysis to identify and present data on the target market. Successful sales strategies have been mentioned that will help you do business in record time and multiply customers.

    This report is presented clearly and concisely to help you better understand the structure and dynamics of the market. The trends and recent developments in the Plumbing Hardware market were analyzed. The opportunities that lead to the growth of the market were analyzed and presented. Focusing on the global market, the report provides answers to the key questions stakeholders are facing today around the world. Information on market size raises the problem of increasing competitiveness and hampering market-leading sectors and market growth.

    Get Exclusive Sample of Report on Plumbing Hardware market is available @ https://reportsglobe.com/download-sample/?rid=162540

    Some of the Important and Key Players of the Global Plumbing Hardware Market:

    Plumbing Hardware market research report provides detailed information on the following aspects: Industry Size, Market Share, Growth, Segmentation, Manufacturers and Advancement, Key Trends, Market Drivers, Challenges, Standardization, Deployment Models, Opportunities, Strategies, Future Roadmaps and Annual Forecasts to 2027, etc. The report will help you also in understanding the dynamic structure of the Plumbing Hardware market by identifying and analyzing market segments. The Global Plumbing Hardware 2021 Industry Research Report has given the expected compound annual growth rate (CAGR) as a% of value for a given period of time and clearly helps the user make their decision based on the futuristic chart of the key players on the global Plumbing Hardware market. The report introduces some of the major players in the global Plumbing Hardware market and offers insightful information about the Plumbing Hardware industry such as Business Overview, Plumbing Hardware Market Product Segmentation, Revenue Segmentation, and the Latest Information. Developments.

    Additionally, the Plumbing Hardware market report includes a comprehensive strategic review as well as summarized studies of the growth, key factors, and market opportunity by which to evaluate the Plumbing Hardware market and other important market related details on Plumbing Hardware. The investigation of the research report also helps uncover accurate industry statistics depicting the ultimate model of the global Plumbing Hardware market, including various types, applications, market growth structures, and opportunities. In addition, the study of the market research report provides an investigation and analysis of the past and current performance of the regional market that includes regions by department and subdivision. This regional analysis studies various key market parameters such as Plumbing Hardware market growth rate in each region, production volume and capacity, market demand and supply, and return on investment (RoI).

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    Some of the key questions answered in the report include-

    1. What is the overall structure of the market?2. What was the historical value and what is the forecasted value of the market?3. What are the key product level trends in the market?4. What are the market level trends in the market?5. Which of the market players are leading and what are their key differential strategies to retain their stronghold?6. Which are the most lucrative regions in the market space?

    Browse the complete report @ https://reportsglobe.com/product/plumbing-hardware/

    Global Plumbing Hardware market is segmented based by type, application and region.

    Plumbing Hardware Market Segmentation, By Type

    Plumbing Hardware Market Segmentation, By Application

    The prime objective of this report is to help the user understand the market in terms of its definition, segmentation, market potential, influential trends, and the challenges that the market is facing. Deep researches and analysis were done during the preparation of the report. The readers will find this report very helpful in understanding the market in depth. The data and the information regarding the market are taken from reliable sources such as websites, annual reports of the companies, journals, and others and were checked and validated by the industry experts. The facts and data are represented in the report using diagrams, graphs, pie charts, and other pictorial representations. This enhances the visual representation and also helps in understanding the facts much better.

    Global Plumbing Hardwaremarket Key Report Highlights:

    This in-depth research documentation offers an illustrative overview of the entire market outlook with details on scope, executive summary, and market segments The report also includes sections on the competitive spectrum, highlighting major players, with a detailed assessment of supply chain management, competition dynamics, and growth objectives. Other crucial details on Porters Five Forces assessment, SWOT analysis, and data triangulation methods have also been included in the report. Other relevant details on production patterns, growth rate, market share of each of the segments have also been pinned in the report. The report also houses crucial analytical details on revenue share and sales projections, besides volumetric estimations of each of the product segments have also been highlighted in the report to encourage unfaltering market decisions and sustainable revenue streams in the global Plumbing Hardware market.A dedicated chapter on COVID-19 analysis has therefore been included in this versatile report to encourage future-ready business discretion aligning with post-COVID-19 market environment.

    Major Points from Table of Content:

    1. Executive Summary2. Assumptions and Acronyms Used3. Research Methodology4. Plumbing Hardware Market Overview5. Plumbing Hardware Supply Chain Analysis6. Plumbing Hardware Pricing Analysis7. Global Plumbing Hardware Market Analysis and Forecast by Type8. Global Plumbing Hardware Market Analysis and Forecast by Application9. Global Plumbing Hardware Market Analysis and Forecast by Sales Channel10. Global Plumbing Hardware Market Analysis and Forecast by Region11. North America Plumbing Hardware Market Analysis and Forecast12. Latin America Plumbing Hardware Market Analysis and Forecast13. Europe Plumbing Hardware Market Analysis and Forecast14. Asia Pacific Plumbing Hardware Market Analysis and Forecast15. Middle East & Africa Plumbing Hardware Market Analysis and Forecast16. Competition Landscape

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    The inception of Reports Globe has been backed by providing clients with a holistic view of market conditions and future possibilities/opportunities to reap maximum profits out of their businesses and assist in decision making. Our team of in-house analysts and consultants works tirelessly to understand your needs and suggest the best possible solutions to fulfill your research requirements.

    Our team at Reports Globe follows a rigorous process of data validation, which allows us to publish reports from publishers with minimum or no deviations. Reports Globe collects, segregates, and publishes more than 500 reports annually that cater to products and services across numerous domains.

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    Plumbing Hardware Market Size By Analysis, Key Vendors, Regions, Type and Application, and Forecasts to 2027 - NeighborWebSJ

    US HVAC Services Market Share Analysis Of Key Market Participants And Their Competitive Landscape – Murphy’s Hockey Law

    - January 20, 2021 by Mr HomeBuilder

    Overview Of HVAC Services Industry 2020-2025:

    This has brought along several changes in This report also covers the impact of COVID-19 on the global market.

    The HVAC Services Market analysis summary by Reports Insights is a thorough study of the current trends leading to this vertical trend in various regions. Research summarizes important details related to market share, market size, applications, statistics and sales. In addition, this study emphasizes thorough competition analysis on market prospects, especially growth strategies that market experts claim.

    The report offers detailed coverage of HVAC Services industry and main market trends. The market research includes historical and forecast market data, demand, application details, price trends, and company shares of the leading HVAC Services by geography. The report splits the market size, by volume and value, on the basis of application type and geography.

    Heating, ventilation, and air conditioning (HVAC) is the technology of indoor and vehicular environmental comfort. Its goal is to provide thermal comfort and acceptable indoor air quality. HVAC system design is a subdiscipline of mechanical engineering, based on the principles of thermodynamics, fluid mechanics and heat transfer.The growing demand for HVAC replacements in developed countries will drive the growth prospects for the global HVAC services market until the end of 2021. The market is witnessing a huge shift towards the reduction of operating costs, increasing energy efficiency, and utilizing the favorable government incentives to replace existing heating, ventilation, and air conditioning (HVAC) equipment in various countries such as the US, the UK, Germany, and Japan. Also, the regulations about the use of refrigerants and energy efficiency will increase the number of investments in the replacement of old HVAC systems. Furthermore, reducing the Freon, other CFC refrigerants production, energy consumption during peak summers, and utility costs by at least 15% will influence the need for replacing the existing HVAC equipment, which, in turn, will accelerate the revenue generation in global HVAC services market.APAC accounted for the majority market share during 2019 and will continue to dominate the market during the forecasted period. Some of the major factors responsible for the growing demand for HVAC installation services in APAC includes rising investments in the real estate sector, the constant demand for infrastructure projects in terms of quality and quantity, the trend for urbanization, and the improved connectivity between different regions.

    Get a Sample PDF copy of the report @ https://reportsinsights.com/sample/251089

    HVAC Services Market competition by top manufacturers as follow:CarrierDAIKIN INDUSTRIESIngersoll RandJohnson Controls International

    The global HVAC Services market has been segmented on the basis of technology, product type, application, distribution channel, end-user, and industry vertical, along with the geography, delivering valuable insights.

    Market segment by Regions/Countries, this report coversNorth AmericaEuropeChinaRest of Asia PacificCentral & South AmericaMiddle East & Africa

    Major factors covered in the report:

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    Our report offers:

    Market share assessments for the regional and country level segments. Market share analysis of the top industry players. Strategic recommendations for the new entrants. Market forecasts for a minimum of 9 years of all the mentioned segments, sub segments and the regional markets. Market Trends (Drivers, Constraints, Opportunities, Threats, Challenges, Investment Opportunities, and recommendations). Strategic recommendations in key business segments based on the market estimations. Competitive landscaping mapping the key common trends. Company profiling with detailed strategies, financials, and recent developments. Supply chain trends mapping the latest technological advancements.

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    US HVAC Services Market Share Analysis Of Key Market Participants And Their Competitive Landscape - Murphy's Hockey Law

    5 Best Window Cleaners in Jacksonville – Kev’s Best

    - January 20, 2021 by Mr HomeBuilder

    Below is a list of the top and leading Window Cleaners in Jacksonville. To help you find the best Window Cleaners located near you in Jacksonville, we put together our own list based on this rating points list.

    The top rated Window Cleaners in Jacksonville are:

    Reflections Window & Pressure Washing knows how important it is to keep your property cleaned and maintained. Not only will it maintain your place looking beautiful, but it can also defend it against the buildup of hazardous mold or bacteria. They want to take the hassle of exterior cleaning off of your shoulders with their pressure cleaning in Jacksonville. There are also other services that they offer to keep the whole exterior of your property cleaned and protected.

    Having clean windows at your home or business is very important to maintain its value. Their window cleaning team knows exactly how to professionally clean your windows in Jacksonville. As one of the pioneers of their industry, they truly value their customer relationships. they look forward to scheduling an appointment with you.

    Products/Services:

    Residential, Commercial, Window Cleaning, Roof Cleaning, Pressure Washing

    LOCATION:

    Address: 11246 Distribution Ave E STE 18, Jacksonville, FL 32256Phone:(904) 322-8900Website: http://www.reflectionsjax.com

    REVIEWS:

    They showed up on time and finished quickly, but not rushed. The house and driveway look great. They paid careful attention to the ceilings of the patios and were able to remove all bio-matter. They did a great job in handling some billing confusion, which they cleared up quickly. Chuck N.

    Window Cleaning By David Cottingham will come out to your home or business at your convenience to discuss your needs, take a close look at your windows and give you an exact quote, no hidden surprises. They arrange an appointment time that fits your schedule and David will personally arrive on the job site, on time, to do the work that you hired him to do to clean your windows.

    He guarantees your satisfaction for an entire week afterward. Though the level of service and attention to detail that he provides is hard to match, he could have missed a spot. David takes your home and his business seriously. Furthermore, to have clean windows, you can have peace of mind that you are dealing with a professional business that cares about your protection.

    Products/Services:

    Residential Window Cleaning, Commercial Window Cleaning, Screen Cleaning & Special Services

    LOCATION:

    Address: 3152 College St, Jacksonville, FL 32205Phone:(904) 680-4993Website: http://www.windowcleaningjax.com

    REVIEWS:

    David has been coming to our house for 3 years to clean our windows. He spends many hours cleaning all of our screens and windows as well as plenty of second-story windows. He is very thorough and will gladly go back over any areas if you have any concerns. His quality and attention to detail is exceptional. He does it right and I will not hesitate to have him come out for many years to come. You will be extremely happy with your decision to work with him. Dan T.

    Top Notch Window Cleaning & Pressure Washing is an owner-operated cleaning company specializing in window cleaning and pressure washing, while also offering many different services to Jacksonville and surrounding areas. Window Cleaning is a common service and is considered at least every 6 months on the exterior of your home. This eliminates debris and hard water deposits that can cause permanent etching damage.

    They use pure water when cleaning, which helps attract contaminates on your glass and rinse away oxidation on your frames leaving a beautiful streak-free shine! It will leave your windows sparkling longer. or make the process as easy as possible for their customers they offer same-day quotes sent directly to your email for viewing.

    Products/Services:

    Window Cleaning, Power Washing, Epoxy Flooring, House & Roof Washing

    LOCATION:

    Address: 13339 Mt Pleasant Rd, Jacksonville, FL 32225Phone:(904) 719-1969Website: http://www.professionalwashingservice.com

    REVIEWS:

    Top-notch is truly an understatement for these two young men and their business Our house, the driveway and the garden rocks around our Flower garden area look phenomenal !!. The extra attention given to our home was simply overwhelming. It feels like we have a brand new home. I highly recommend the services that this Company has to offer to anyone that is needing pressure washing, window cleaning, or even the garden rocks cleaned around their garden. Keeping in mind they do so much more.Top Notch is a Very professional company.And come highly recommended. Kim P.

    Jax Elite Home Services is a locally owned and operated company that has more than ten years of experience in providing Northeast Florida with an order of property cleaning and maintenance services. They are a team of professionals that works hard to provide each of their clients with top-of-the-line services. They take pride in offering the best services and understand that for their services to be truly elite, they must provide excellence at every step of the way.

    At Jax Elite, they dont have customers, they have clients. And their clients count on them for the expertise and professionalism their homes and businesses deserve. They have built their business on the idea that if they combine years of property cleaning and maintenance experience with industry-leading equipment and state of the art technology, they can provide Elite services to each and every one of their clients.

    Products/Services:

    Window Cleaning, Pressure Washing, Gutter Cleaning, Dryer Vent Cleaning

    LOCATION:

    Address: 2137 Saye Dr, Jacksonville, FL 32225Phone:(904) 484-8288Website: http://www.jax-elite.com

    REVIEWS:

    We retained Jax Elite home services for a full house exterior pressure wash, window wash and gutter cleaning. We werent quite sure what to expect and the team did a superb job. The workers were very responsible and were careful not to damage anything in the pressure washing process. Our house is white and had gotten quite dirty on the outside. It now looks like new, and we cant believe what a difference it makes! The price was very reasonable for all the work they did. We would definitely recommend Jax Elite Home Services. Gina S.

    Inside Out Property Solutions is a chief locally owned and operated total service cleaning company that has been servicing residential homes and commercial buildings in Jacksonville, Florida, and all surrounding areas since 2003. They offer exterior and interior window washing, janitorial services, home, and building maintenance and repair, and pressure washing with first-class customer service to Northeast Florida from Ortega to Ponte Vedra and St. Augustine to Amelia Island.

    Just tell them what you would like to do to improve the appearance or function of your home or business from the roof to the floor, from the windows to the walls, and they will be happy to help you.

    Products/Services:

    Window Cleaning, Roof Cleaning, Interior & Exterior Painting, Home Soft Washing

    LOCATION:

    Address: 6905 Madrid Ave, Jacksonville, FL 32217Phone:(904) 723-0039Website: http://www.insideoutww.com

    REVIEWS:

    James and his crew are the best! Highly recommend this company for all your pressure washing/window cleaning needs! Wendy C.

    Shera Elliott graduated from the New Mexico State University with a major in biology and a minor in Biological Basis of Behavior & Health Care Management. Shera grew up in Los Angeles, but moved to Las Cruces for college. Shera has written for several major publications including the Albuquerque Journal and NPR. Shera is a community reporter and also covers stories important important to all Americans.

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    5 Best Window Cleaners in Jacksonville - Kev's Best

    Time To Start Fresh: Follow These Steps To Deep Clean Your Space : Life Kit – NPR

    - January 20, 2021 by Mr HomeBuilder

    Many of us are spending a lot more time at home than in years past. And if you've noticed dust bunnies, streaky windows or that pile of clothes that keeps getting higher, now's a great time to clean house.

    We spoke to Taryn Williford, the lifestyle director at Apartment Therapy, about how to deep clean any space.

    Williford says figuring out what you want to get done and why is the first step. "Step back, zoom out and figure out your goals and really get your mindset into shape," she says. Maybe it's a nightly wipe downs of kitchen counters, a weekly clean of the bathroom or a monthly deep clean of your whole house. Identifying what you want ahead of time makes it easier to get down to it.

    Before you start deep cleaning, do some basic tidying up. Remember the maxim, "A place for everything and everything in its place." Williford says when everything is where it should be, it saves a lot of time when you actually start cleaning.

    And you can arrange your stuff according to how you use it. She says she remembers a comment a reader left at the end of an article on Apartment Therapy: "Don't change your habit, change your habitat." Williford says that helped her realize that it was OK to put a hamper in the living room, if that was where she was most likely to remove her socks. "I realized I can kind of choose to design my home around my life, instead of designing my life around my home."

    You need an all-purpose cleaner, a disinfectant and a window cleaner, Williford says: That all-purpose cleaner will work on most surfaces in your home. The disinfectant will attack germs in places like inside the toilet or on the kitchen counter. And the window cleaner is formulated to make sure that it doesn't leave streaks or deposits.

    She says you don't even need these products to be specialty label cleaners you can use vinegar (cuts through mineral deposits), baking soda (great for dissolving grease and oils), and dish soap (perfect for bathroom tiles or stained tubs).

    A few microfiber cloths will do nicely, as well as a scrub brush, a mop and a vacuum or broom. She says you may also need a duster (or you can improvise with a sock!).

    Williford also keeps handy a razor blade (to scrape off something that's stuck), a cocktail pick (to get to tiny crevices) and squeegee (for glass shower doors and windows).

    Williford suggests starting with the kitchen and bathroom. "They're the most important rooms to clean and to clean properly," she says. Make sure you clean all counter tops, the front of the fridge and cabinets and even trash cans. Go clockwise so you don't miss any surfaces or furniture.

    Another rule of thumb is to go top to bottom. So, for example, in the bedroom, clean the light fixtures and the fan before stripping the beds. Williford learned that lesson the hard way when she first started by taking off all the bedsheets. "All the dust would fall on my bare mattress!"

    Make sure to dry clean before you wet clean. For example, you want to dust your blinds first before using your all-purpose spray. "And the reason for that is, if you start straight in with your wet cleaners and you haven't dusted that surface, you're going to end up getting all that gunk on your rag and you realize, 'oh, this rag is filthy' and you end up having to switch out rags more often. It's just really not efficient," Williford says.

    Finally, sweep or vacuum the rugs and floors and then mop.

    Williford says getting into a routine helps make deep cleaning less intimidating. Set a schedule for daily, weekly and monthly cleaning tasks.

    Daily tasks might include picking things up, cleaning kitchen surfaces, doing those dishes and cleaning the shower. Weekly tasks might include cleaning the bathroom, dusting surfaces all over your home and washing sheets and towels.

    Nothing compares to the feeling of a squeaky clean home, Williford says. "When the kitchen's clean, it makes cooking that much easier. When the sheets have been washed, it makes getting to bed on time easier," she says.

    A clean home can positively impact your health, your sleep and your hobbies. "A perfectly clean home really makes you feel like you can do anything!" she says.

    The podcast version of this story was produced by Sylvie Douglis.

    We'd love to hear from you. Leave us a voicemail at 202-216-9823, or email us at LifeKit@npr.org.

    For more Life Kit, subscribe to our newsletter.

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    Time To Start Fresh: Follow These Steps To Deep Clean Your Space : Life Kit - NPR

    How to clean windows with white vinegar – Express

    - January 20, 2021 by Mr HomeBuilder

    White vinegar is extremely acidic, and that is what makes it such a good natural cleaner. It can dissolve stubborn watermarks, soap scum, and other nasty build-ups in no time at all and doesnt damage the environment. Dirt, dust and grime gather on your windows - indoors and outdoors - reducing natural light and blurring the view.Express.co.ukreveals how to clean your windows with white vinegar.

    If you look at the eco-friendly window cleaning products on the market, lots of them will be made with white vinegar.

    White vinegar is known for leaving your windows shiny and water-mark-free.

    However, its important to note that while white vinegar has some antibacterial properties, it cant kill all bacteria and viruses it encounters.

    For this reason, you should probably clean your windows with something stronger first and treat white vinegar as a finishing touch.

    READ MORE- White vinegar for cleaning: 8 things you can clean with vinegar

    Take a lint-free cleaning cloth or paper towel and rub the vinegar into the window in a circular motion.

    Make sure you work quickly, as taking too much time can leave streaks.

    Use a microfiber cloth to dry the window, but work in straight vertical lines from the top to the bottom rather than using a circular motion.

    Dry the window as quickly as you can to avoid streaks

    Dont use a tea towel or regular cloth, if you dont have a microfiber cloth you can simply use a kitchen towel or paper towel.

    See the article here:
    How to clean windows with white vinegar - Express

    Banned driver jailed after getting behind the wheel to collect window cleaning equipment – North Wales Live

    - January 20, 2021 by Mr HomeBuilder

    A motorist disqualified for dangerous driving was caught on a road miles from home collecting equipment for his window cleaning business.

    Paul Simon Campbell, 29, had been banned and given a suspended prison sentence last year after leading police on a high speed chase around Colwyn Bay.

    But he ignored the three-year disqualification and was caught in his Renault van by Cheshire Police near Chester heading towards North Wales.

    Today a judge at Caernarfon Crown Court said he had been "stupid" and activated part of his suspended sentence and gave him a further term for driving while disqualified. He must serve a total of five months and two weeks in prison.

    The court heard Campbell had been caught on September 28, 2019 after going the wrong way around a roundabout and being pursued by police.

    Last February, Caernarfon Crown Court heard Campbell admit dangerous driving. He was given a 12-month prison term, suspended for 18 months, and banned from driving for three years.

    But today the same court was told that Campbell had been stopped by Cheshire Police on the A550 near Chester heading towards North Wales on September 27, 2020.

    He told the officers he was disqualified and had no insurance.

    Campbell, of Kensington Avenue, Old Colwyn, said he ran his own window cleaning business and was collecting second hand equipment.

    He was arrested and charged with driving while disqualified, having no insurance and failing to comply with a suspended sentence order.

    Sarah Yates, defending, said Campbell's behaviour had been "unimpressive" and he is extremely remorseful.

    She said: "He was trying to start a window cleaning business. In doing so he made the silly mistake of driving his vehicle to pick up some equipment." He has two children and a stepchild to support.

    The judge told Campbell he was turning his life around and had made progress towards being rehabilitated.

    She jailed Campbell for four months of his original sentence and a further one month and two weeks for driving while disqualified. There was no separate penalty for driving without insurance.

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    Banned driver jailed after getting behind the wheel to collect window cleaning equipment - North Wales Live

    Cleaning Robots Market to Remain Lucrative During 2020-2026 – The Courier

    - January 20, 2021 by Mr HomeBuilder

    The Cleaning Robots market provides a detailed outlook on sales and trends forecast for 2020-2026:

    As the world continues to deal with COVID-19, economies are moving into recession, under multiple adverse factors, the GDP of European and American countries in the second quarter suffered a historical contraction. At an annualized rate, the US GDP fell by 32.9% month on month, while the overall GDP of the euro zone fell by 12.1%.

    Moreover, the economic prospects of Europe and the United States in the third quarter under the epidemic situation are hardly optimistic. The resumption of work and production not only brought economic data back, but also triggered a rebound in the epidemic situation. At present, the United States is still the 'epicenter' of the global epidemic. The total number of confirmed cases has exceeded 4.8 million, and the epidemic situation in some European countries has also rebounded. Affected by this, more than 20 states in the United States have announced the suspension or withdrawal of part of the economic restart plan. Britain and Italy have also decided to extend the state of emergency. The rebound of the epidemic situation has posed considerable risks to the economic prospects of Europe and the United States.In the second quarter of this year, US GDP shrank by 9.5% on a month on month basis, or 32.9% at an annual rate, the largest decline since the 1940s. Data show that the sharp decline in personal consumption is the main drag on the U.S. GDP growth in the second quarter.

    Regal Intelligences latest report on Cleaning Robots industry includes an analysis of the impact of COVID-19 on the global marketplace. The report provides the market prospects for todays market scenario and however, the key global suppliers are expected to establish a superior acceptable marketing strategy. This Cleaning Robots research study has identified constantly evolving market factors that are expected to influence market growth. In addition, market performance and key dynamic components are assessed in this report to assist in making informed business decisions.

    The significant players covered in this report are: iRobotEcovacsProscenicMatsutekNeato RoboticsInfinuvoLGSamsungSharpMamirobotFunrobotYujin RobotVorwerkPhilipsFmartHanool RoboticsMieleKarcherFluidra(AstralPool Robots)HaywardPentairToshibaDyson

    It is expected that key players will improve their marketing capabilities over the next two years as a result of some Cleaning Robots market conditions. The report outlines what will reflect what is happening and how such changes in the marketplace will occur. Furthermore, the report looks at upstream raw materials, downstream demand, and production value of the main players subject to market growth.

    Go To Sample Report of Cleaning Robots Market @ https://www.regalintelligence.com/request-sample/195125

    Cleaning Robots Marketplace Primary End-users: HomeOfficeOther

    Cleaning Robots Market Segment according to Product Types: Floor Cleaning RobotsPool Cleaning RobotsWindow Cleaning RobotsLawn Cleaning Robots

    The period under consideration for estimating the market size of the Cleaning Robots is as follows:

    History Year: 2015-2019|Base Year: 2019|Estimated Year: 2020|Forecast Year 2020 to 2026

    Market Subdivision:

    The global market Cleaning Robots is segmented according to the kind of product, application, and region. The analysts who draft the report do a meticulous assessment of each segment mentioned. The Segments are studied according to their market share, revenues, regional growth, cost and revenue analysis, and other critical factors. The segmentation study identifies the fast-growing segments of the global market Cleaning Robots and understands how the market can grow during the forecast period.

    Predominant Objectives of Cleaning Robots Marketplace Report:

    For Further Information about this Report: https://www.regalintelligence.com/enquiry/195125

    In summary, the report presents key geographic areas, the competitive landscape consistent with demand and supply analysis, the rate of market growth, and a future prediction for forecast years. The report examines the BCG, SWOT along PESTLE to assess market profitability and growth rate. The report also assists investors in the analysis of investment feasibility and yield analysis.

    Excerpt from:
    Cleaning Robots Market to Remain Lucrative During 2020-2026 - The Courier

    No one wants to do it but here are tips for deep cleaning your bathroom – Utica Observer Dispatch

    - January 20, 2021 by Mr HomeBuilder

    By Deb Cabral| Special to the Observer-Dispatch

    Woman cleaning grave markers is oddly satisfying

    Alicia Williams started cleaning old grave markers as a hobby. Hundreds of markers later, she has thousands of online fans entranced by her technique.

    Humankind, USA TODAY

    The bathroom can be one of the most germ-filled rooms in the house. Even when the room looks neat and orderly, germs can be lurking everywhere. Here are some strategies for giving the bathroom a good, old fashioned deep cleaning.

    Start with the shower. Its best to start at the top with the showerhead. Fill a plastic bag with vinegar and place it over the showerhead, using a rubber band to hold it in place. Leaving it overnight, remove it in the morning and run the shower to rinse it. The showerhead should be as clean as a whistle. Clean the tub and tile with your bathroom cleaner of choice and wipe with a microfiber cloth. If you have a shower door(s), make a paste of baking soda and vinegar and rub the mix with a sponge on both sides of the door and inside the track. Let sit for 30 minutes to an hour and rinse. Put the shower curtain and liner in the washing machine on delicate with detergent and a small amount of bleach. Spin dry both items on low. Clean the shower curtain rings by soaking them in the sink with dish detergent and a splash of bleach. Now your shower will be fresh and clean.

    Tile, countertop, walls and ceiling. A build-up of soap and even dead skin cells can be on all of these surfaces. Gross, but true. Spray all of these areas with an all-purpose cleaner. Turn on the shower and run the water until it causes steam for at least five minutes. Then shut off the shower and leave the room, closing the door behind you. Let the steam do its work for at least 20 minutes. Then wipe down all surfaces with a clean cloth. Use a microfiber mop to reach the high spots.

    Dont forget the grout. Grout is porous and can be a haven for bacteria. Using a toothbrush and bleach, scrub all the grout, especially those that may be discolored. Let the bleach sit for a few minutes and rinse with hot water. For those that do not like to use bleach, hot water and vinegar will do the trick too, but leave it on for at least an hour before rinsing. Open the window to keep fresh air coming into the room, if you choose to use bleach.

    Save the best for last (not really!) the toilet. Pour a full cup of baking soda into the toilet and let it sit for 10 minutes. Using a toilet brush (my favorite is one that IKEA sells for $1.99), scrub and clean all areas of the toilet and then flush. Dont forget to clean the toilet brush. Poor bleach over a sink onto the brush works best, but if youd prefer not to use bleach, vinegar and hot water can be a suitable substitute. Using a Lysol wipe, clean the seat and all of the outer parts of the toilet, including the base. Then wash down with a rag with hot water and dry.

    Wash the hand towels. Its best to wash your hand towels on the sanitizing setting, if your washing machine has that setting, especially during the pandemic. Replace hand towels every few days to avoid the spread of bacteria. Clean the towel bar as well.

    Having a clean bathroom helps keep bacteria at bay and you and your family healthy!

    Look for more tips from Deb in the Observer-Dispatch every Sunday and on her websites decluttercoachdeb.com and dceffconsult.com. You can follow her on social media and watch her TV show Organization Motivation! organizationmotivation.com.

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    No one wants to do it but here are tips for deep cleaning your bathroom - Utica Observer Dispatch

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