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Bolivia: Report sheds light on privatization of public entities in 90s
The Legislative Assembly in Bolivia closed its session with a report about the privatization of public companies during the rise of neoliberalism in the 1990...
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Strong Workshop Sheds
Strong Sheds and Workshops made to measure to suite your exact needs . Full nationwide supply and fitting available. All our timber buildings are available in at least three different qualities...
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FORT WASHINGTON, Pa., Jan. 16 (UPI) -- Soap opera icon Genie Francis has revealed she lost 30 pounds using Nutrisystem.
"I've always been an emotional eater. I use food to comfort myself. It's been an ongoing problem in my life," Francis, a spokeswoman for the weight-management company, said in a statement Thursday.
"But the biggest part of the problem was that before, in order to lose weight, I would do extreme diets and starve. The good thing about Nutrisystem is that I'm more at peace with food," she added. "I know how to eat the right amount of breakfast, lunch and dinner. I avoid triggers and stay away from button foods -- the ones that make you want to eat more. The fact that I get to eat the foods I love on Nutrisystem satisfies my cravings and I am less vulnerable to those button foods."
Francis, 52, is best known for her roles on the daytime dramas The Young and the Restless and General Hospital.
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IMAGE:This is Diane M. Simeone, M.D., University of Michigan Comprehensive Cancer Center. view more
Credit: University of Michigan Comprehensive Cancer Center
ANN ARBOR, Mich. - New research from the University of Michigan Comprehensive Cancer Center helps explain why pancreatic cancer is so lethal, with fewer than a third of patients surviving even early stage disease.
The researchers found a gene known to be involved in nearly 90 percent of pancreatic cancers promotes cancer growth and spread. The gene, ATDC, plays a key role in how a tumor progresses from a preinvasive state to an invasive cancer to metastatic cancer.
"We know that patients with the earliest stage of pancreatic cancer have a survival rate of only 30 percent. This suggests that even in that very early stage of invasive cancer there are already cells that have spread to distant parts of the body," says study author Diane M. Simeone, M.D., director of the Pancreatic Cancer Center at the University of Michigan Comprehensive Cancer Center.
"This study sheds important light on what it is about pancreatic cancer that makes it so aggressive early in the game," she adds. The study appears Jan. 15 in Genes and Development.
Researchers used a mouse model to replicate pancreatic cancer as it appears in humans. They also studied pancreatic cancer tissue samples and samples of pre-invasive pancreatic lesions. They found ATDC was expressed in a subset of the pre-invasive cells and played a role in the development of pancreatic cancer stem cells, the small number of cells in a tumor that fuel its growth and spread. This suggests that ATDC promotes a tumor's invasiveness and spread early in the course of disease.
The researchers suspect that ATDC may be a potent drug target. No drugs currently exist to target this pathway in part because researchers do not understand the crystal structure of the protein. Simeone's team, working with the University of Michigan Center for Structural Biology has made crystals of the protein and begun to create a three-dimensional structure that they can use as a model for drug development.
Preliminary data suggests that ATDC may also play a role in other cancer types, including bladder, ovarian, colorectal and lung cancers and multiple myeloma. But, Simeone notes, it's particularly critical to find new treatment options for pancreatic cancer. About 46,400 Americans will be diagnosed with pancreatic cancer this year, and more than 39,000 will die of the disease. Pancreatic cancer is expected to become the second-leading cause of cancer death in the United States by 2030.
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What makes pancreatic cancer so aggressive? New study sheds light
By Tanya Jefferies for Thisismoney.co.uk
Published: 04:59 EST, 15 January 2015 | Updated: 08:04 EST, 15 January 2015
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The oil price crash has sparked fears of widespread job cuts as industry giant BP shed 200 staff and 100 contractors.
Joining Shell, Tullow and Premier in announcing a shake-up of operations, BP said the job cuts apply to onshore roles not offshore operations.
Politicians in Westminster and Scotland are being pressed to take urgent action as BP announced the job reductions at a briefing today at the firm's North Sea headquarters in Aberdeen.
Oil price crash: Dramatic fall has caused upheaval on world markets but lower petrol costs are expected to drive a consumer boom that ultimately helps the economy
Other firms under the cosh include Tullow Oil, which today wrote off 2billion of exploration work and cut investment amid expectations of job cuts, Royal Dutch Shell which has axed a 4.3billion project in Qatar, and Premier Oil which slashed spending by 40 per cent and wrote off nearly 200million yesterday.
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BP sheds 300 jobs as industry struggles with $49 oil price
Former NFL pro is barely recognizable as he sheds 124lbs on The Biggest Loser
Former NFL pro Scott Mitchell is barely recognizable after shedding an impressive 124lbs - roughly the weight of 138 footballs. The 47-year-old ex-athlete fr...
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A tiny Siberian fish fossil thats a whopping 415 million years old may be part of a group of fish that was ancestor to all the jawed vertebrates living today, according to a team of European scientists.
Described online in the journal Nature, the fossil fish, Janusiscus schultzei, could help researchers flesh out - and perhaps redraw - portions of the ancient fish family tree.
The fossil, discovered near the Sida River in Siberia in 1972, is a strange, chimeric mishmash of features of very different lineages, which makes it valuable to scientists who have long struggled to sort out the ancient fish family tree between 443 million and 358 million years ago, during the Silurian and Devonian periods.
The vast majority of fish in the Earths waters today are bony fishes descendants of a group known as osteichthyans. But back in fishes heyday, around 400 million years ago, osteichthyans werent the only group around. There were also cartilaginous fish called chondrichthyans (whose descendants include sharks and rays) as well as extinct armored fishes called placoderms.
These different groups of fish were all descended from gnathostomes, or jawed fish, and scientists want to know what those ancestral gnathostomes look like in part because the answer could affect how we see our own origins.
Heres a brief family history. Osteichthyans, the bony fishes, split into two main groups the ray-finned fishes, which make up the vast majority of fish in the ocean today, and the lobe-finned fishes, whose descendants eventually crawled onto land. Those descendants, the "tetrapods," evolved into all four-legged vertebrates on Earth today, from reptiles to mammals (and, yes, including humans).
So what did the ancient ancestors of all jawed vertebrate life on Earth today look like? It was long thought that gnathostome species would look more like the cartilaginous chondrichthyans their living members, the sharks, are seen as "primitive," living fossils that havent changed much over time. Bony structures, like the ones in our own bodies, appear much more complex, so it was assumed they evolved later. But recent studies have found that shark-like, cartilaginous bodies may have been a later development and that the bony fishes might be the ones who inherited the more primitive traits.
For this study, the researchers subjected the fossil skull of this fish to an X-ray CT scan to examine tell-tale structures in the animals skull. Like other recently examined specimens, the Janusiscus schultzei fish fossil also has a strange mix of features that seem like theyre both from the bony osteichthyans and the cartilage-bodied chondrichthyans.
The structure of the skull roof bones look a lot like those of osteichthyans, but a number of features, including a flat-based braincase, dont match osteichthyans at all. In fact, certain features of the braincase actually look a lot more like those in early chondrichthyan species.
Janusiscus presents an unexpected suite of osteichthyan, chondrichthyan and generalized gnathostome traits, the study authors wrote.
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The rise of jaws? Tiny fossil sheds light on fishy origins
Home Movies Divergent First Insurgent featurette sheds light on mystery box, introduces Fours mother
A lengthy behind the scenes look at Insurgent explains the mystery box first seen in the trailer and where we find Tris and Four at the beginning of the film.
Amongst lots of behind the scenes footage are several highlights: A great fight between Peter and Tris, as well as our first look at Naomi Watts in the role of factionless leader Evelyn (the mother of Four).
Were also promised no more world building a frequent complaint about the first film, Divergent.
The great thing about this movie is that weve gone through the setup of this world, says Four actor Theo James. Adds Ansel Elgort, who plays Tris brother Caleb, We already have all of the characters introduced. Now we can just tell a great story.
The movie begins with Tris being chased amongst factions and never let[s] up, according to producer Lucy Fisher. Like the book, the films story begins in Amity where Tris and Four are taking refuge. We see the unveiling of Tris new haircut and several simulation sequences including the one found in the teaser trailer. Douglas Wick, the films second producer, confirms that Tris and Four will be brought to the factionless compound but its not clear if they get there by jumping into a train coincidentally full of factionless like in the book.
As for that mystery box seen in the second trailer which left lots of fans stumped? The box takes a lot of my favorite scenes from the book and puts them in the same place at the same time, author Veronica Roth explains.
In the first movie you dont really know exactly what Erudite is up to. In Insurgent, its crystal clear, adds Kate Winslet who plays Jeanine.
These comments fit with a theory one of Hypables readers presented when the mystery box appeared in the trailer. The reader believes that the Edith Prior video, found by Tris and Four at the end of the Insurgent book, is in the box, and Jeanine needs someone with three faction aptitudes, like Tris, to open it. For the film, Tris is probably the only character capable of opening it.
Insurgent opens in theaters this March.
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First Insurgent featurette sheds light on mystery box, introduces Fours mother