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    JNCCN study sheds light on multi-organ adverse events from immunotherapy – The Cancer Letter - September 11, 2020 by Mr HomeBuilder

    publication date: Sep. 11, 2020

    A study published in the Journal of the National Comprehensive Cancer Network adds important knowledge about how immunotherapy-related adverse events can impact more than one organ in a single patient.

    This study provides new information on how frequently multiple organ side effects occur, and reveals that multi-organ irAEs are more likely to happen sequentially rather than simultaneously.

    Multi-organ irAEs are under-recognized, under-reported, and their pathophysiology is poorly understood, lead researcher Ganessan Kichenadasse, of Flinders Centre for Innovation in Cancer, Flinders University, Australia, said in a statement. We need a concerted international effort to improve our understanding and help identify predisposing factors and prevention strategies. Treating teams should be aware of the potential for irAEs which affect multiple organs and institute plans for recognizing and managing them.

    The researchers evaluated the incidence and patterns of multi-organ irAEs using individual patient data from four non-small cell lung cancer trials where patients were treated with atezolizumab, a PD-L1 inhibitor. Those four studies, known as OAK, POPLAR, BIRCH, and FIR, include investigators from around the world. Out of 1,548 patients worldwide, 27% experienced at least one adverse event; 5.4% experienced multi-organ irAEs. Skin, laboratory, endocrine, neurologic and pulmonary abnormalities represented the most common organ systems involved.

    Among the 84 cases with multi-organ irAEs, 70 patients (83.3%) had two organ systems affected, 13 (15.5%) had three, and one patient had four systems affected. 86% of multi-organ irAE patients experienced these side-effects sequentially rather than concurrently. According to the results, multi-organ irAEs were generally amenable to satisfactory management, and their occurrence was associated with better overall survival rates.

    Based on the Continue reading JNCCN study sheds light on multi-organ adverse events from immunotherapyTo access this members-only content, please log in.Institutional subscribers, please log in with your IP.If you're not a subscriber why not join today?To gain access to the members only content click here to subscribe.You will be given immediate access to premium content on the site.Click here to join.

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    Sheds taking on the role of offices and classrooms amid pandemic – 69News WFMZ-TV - September 11, 2020 by Mr HomeBuilder

    As this COVID crisis enters month six, more and more people are buying prefabricated backyard sheds to use as home offices.

    For some, the sheds are a chance to get work done away from the kids learning remotely, and for others, it's a necessity because there's just no room for an office setup inside their home.

    According to Google, searches for office sheds started to tick higher in April and those searches started trending higher again in mid-August as the country entered the back-to-school season.

    Companies are noticing too. Modern-Shed said there's been a 400% rise in interest this summer.

    Now, these aren't just normal utility sheds.

    A lot of people are choosing to customize their office sheds, so you get to decide what style of wood you'd like to use, where you'd like the windows to be placed and various other options.

    But of course the more you want, the more you pay. For the company Studio Shed, prices are typically around $120 to $180 per square foot.

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    Sheds taking on the role of offices and classrooms amid pandemic - 69News WFMZ-TV

    The Minneapolis Fed sheds its reserve – MinnPost - September 11, 2020 by Mr HomeBuilder

    The president and CEO of the Federal Reserve Bank of Minneapolis isnt content to simply be the purveyor of sound, data-based economic research. Instead of analyzing the Feds Ninth District communities from afar, hes jumped into the mix in community dialogues, and hes willing to accept the public criticism that accompanies his activism.

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    Of course, people who know Kashkari would never accuse him of timidity. He was an assistant secretary of the Treasury in 2008 and 2009, overseeing the Troubled Assets Relief Program during the financial crisis. This was the most unpopular economic program in American history, Kashkari says. But he maintains that the $700 billion federal bailout of banks and other businesses was the right thing to do, and it crossed party lines.

    Since he arrived in Minnesota in 2016 to lead the regional Federal Reserve Bank, Kashkari and his staff have made a concerted effort to change the institutions semi-reclusive image and to engage frequently with a range of citizens. The Fed has done everything from opening a booth at the 2019 Minnesota State Fair to convening local and national leaders tackling the affordable housing issue.

    Kashkari also has entered the political arena, doing so when he believes it will help the Fed fulfill its mandate to achieve maximum employment. I want us to go take on important public policy issues, Kashkari says. If we can make a difference, and we can do it in a bipartisan manner, then thats what were here for.

    His most prominent foray into public policy development is a proposed education amendment to Minnesotas Constitution, which states that all Minnesota children have an equal right to a quality public education.

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    Kashkaris lead partner in advocating for the amendment is retired Minnesota Supreme Court Justice Alan Page, who wrote in a 1993 dissenting court opinion, The States duty toward its children is not satisfied unless it provides equal educational opportunities for all children.

    Kashkari and Page want the Minnesota Legislature to pass a bill in 2021 that authorizes placing an education amendment on the 2022 ballot. The amendment would hold public schools accountable for providing a good education for each child. We believe the political system is what has failed the children of Minnesota, Kashkari says.

    A 2019 Fed report, A Statewide Crisis: Minnesotas Education Achievement Gaps, documented the disparities in achievement for children of color and those from low-income families.

    The study found that only three in 10 African-American students were performing at grade level, while 65 percent of white students met that threshold.

    Regardless of geography, family income plays a huge role in how students are being educated in Minnesota. The Fed study showed that 37 percent of students from low-income families were proficient in math and reading, compared with 68 percent for children from higher-income households.

    Kashkari believes its time to disrupt Minnesotas education system.

    The achievement gap for students of color in urban schools is common knowledge among state politicians, private foundation heads, and business leaders. Yet most interventions theyve made to remedy the problem have not substantially narrowed the gaps.

    A lot of effort and a lot of money has gone into trying to solve these persistent gaps, and it simply hasnt worked, Page says. Both Neel and I think that by changing the constitution it will act as a catalyst to create that [political] will to do something different.

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    Page is a longtime advocate for education. In 1988, he and his wife, Diane, created the Page Education Foundation, which provides scholarships that help many students of color attend college. In turn, the Page Scholars mentor children in grades kindergarten through eighth grade.

    When Kashkari wanted to do something bold to break the inertia in Minnesotas education establishment, he turned to Page for help. Neel invited me to come down to the bank and talk about education, Page recalls. We talked about what other states had done, what their research was showing, what the possibilities were, and what we could do that would have some real impact.

    They zeroed in on a constitutional amendment. They point to other states, including Florida, where they say voter approval of an amendment has exerted pressure on political leaders to achieve real progress in educational attainment.

    Everyone says, We want to put kids first. We want to drive change, Kashkari says. But he expresses frustration that substantive change is often blocked. So were making people put their money where their mouth is. You say that you want to put kids first, and you really want to make changes. Heres your chance, Kashkari says.

    Since Minnesota became a state in 1858, Page and Kashkari argue, education funding and teaching approaches have focused on the education system, rather than on the individual needs of each child in a particular school.

    For the last 30 years, Ive been saying education works best when we focus on one school at a time, one classroom at a time, one child at a time, Page says.

    The state Constitutions current language says, it is the duty of the legislature to establish a general and uniform system of public schools. Kashkari asserts that the state needs to create an individual civil right that each child will receive a good education.

    The proposed amendment says it is a paramount duty of the state to ensure quality public schools that fulfill this fundamental right. It states children would need to meet certain standards or educational outcomes, and the legal underpinning of the amendment would allow parents to hold schools accountable through litigation.

    Page, an Ohio native, was 8 years old when the U.S. Supreme Court decided Brown vs. Board of Education, the landmark ruling that outlawed racial segregation in public schools. While the Brown case shattered the status quo in 1954, Kashkari and Page argue that dramatic change is needed in Minnesotas K12 schools many decades later.

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    Before the coronavirus surfaced early this year, Kashkari was spending considerable time in meetings to build support for the education amendment. But his agenda has broadened because of the historic economic and social challenges that have been unfolding. In recent months, the outspoken Kashkari could be seen in numerous high-profile settings. He was a 60 Minutes guest in March, talking about the huge infusion of government money he thought was needed to respond to the economic crisis caused by Covid-19.

    In May, he appeared alongside epidemiologist Michael Osterholm in a virtual Economic Club of Minnesota event. At that time, he warned it was unrealistic to expect a V-shaped economic recovery and argued Americans would need more direct government benefits because it will take a long time to bring back many jobs and rebuild the economy.

    Shortly before the July 4 holiday, he took part in a National Association for Business Economics webinar on Race, Mobility, and Fairness in the U.S. Economy. During his tenure at the Minneapolis Fed, Kashkari said he doubled the percentage of key leaders who are people of color. As a major part of the Feds mission to promote maximum employment, Kashkari said the Fed should address education, health, and housing problems that limit job opportunities.

    Kashkaris transparency in his communications and public access is a departure from how the Federal Reserve long has operated, particularly in Washington, D.C.

    Our jobs are to serve the public, Kashkari says. We need the public to have confidence in us and what we are doing, and that confidence has to be earned. Historically, the Fed was very buttoned-up and didnt let people look behind the curtain. It was like the Wizard of Oz.

    Kashkari maintains that aloofness had a downside. When the financial crisis hit [in 2008], we really needed people to trust us because we were doing extraordinary things, he says, but many people didnt know much about the Federal Reserve.

    It was very mysterious, and we were never seen, he says. You would just hear these interest rate pronouncements that came out. [Former Chairman] Alan Greenspan intentionally spoke in a very confusing manner to add to the mystery of the Fed.

    Kashkari says succeeding Fed chairs and regional Fed Bank leaders have been taking a different approach. Weve made a conscious effort to communicate more with the public, let them see what we are working on, he says. Just this past year, the board of governors led an initiative called Fed Listens, where we had a series of public forums, where community leaders and policy experts would come and meet with us to talk about how we conduct monetary policy.

    In Minneapolis, in addition to scores of public gatherings on key issues, the Fed has held informal events to meet a range of citizens. The Fed took part in Doors Open Minneapolis, which allowed people to walk around the building and ask questions. It also hosted a booth in the Education Building at the 2019 Minnesota State Fair, where staff listened to people from around the state. Though they lacked a Fed product on a stick, Kashkari says, we did give out bags of shredded money. (The Fed shreds old bills removed from circulation.)

    Increasing engagement with the public is one strategy that Kashkari has championed, but hes surprised some people by going a step further, into policy development.

    We want to make as big a positive impact as we can on our community and on the country in terms of public policy, Kashkari says. Earlier in his Minneapolis tenure, he led a national conversation over banking regulation in the aftermath of the financial crisis.

    Arguing that the biggest banks still pose an economic danger, Minneapolis Fed veterans Ron Feldman and Ken Heinecke authored The Minneapolis Plan to End Too Big to Fail. The plan recommended raising equity capital requirements for large banks with assets over $250 billion.

    In that policy initiatives case, Kashkari says, We didnt get any traction because the regulatory winds in America have been blowing in a deregulatory direction and we were advocating for more regulation.

    Kashkari, one of 12 members of the Federal Open Market Committee, which sets monetary policy including interest rates, says he has guardrails that help him determine his public policy advocacy.

    Leadership on the education amendment fit his test for involvement, he says, because peoples ability to land good jobs is tied to the Feds maximum employment mission. Before moving forward on a major policy initiative, he also weighs three questions: Is this an important public policy issue? Do we have expertise to bring to bear on it? Can we develop a proposal that is nonpartisan?

    More policy proposals are expected to flow from the Opportunity & Inclusive Growth Institute, which Kashkari established at the Minneapolis Fed in 2017. One of my big surprises coming to Minnesota was discovering the disparities, he says. In Minnesota, the median annual household income for whites is about $36,000 higher than the income for Blacks. Kashkari felt compelled to probe the reasons. Its too big of an issue for us not to try and use our really smart economists to try and understand the gap, he says.

    That type of work appealed to Abigail Wozniak, a Harvard Ph.D., who gave up her job as a tenured economics professor at Notre Dame to become the institutes first director in early 2019.

    She didnt want to do academic research in isolation and believes in Kashkaris vision for the Minneapolis Fed thats built on groundbreaking work by former Fed research director Art Rolnick. That research, which showed a high return on investment from early childhood learning, has been used for many years to buttress support for funding preschool programs.

    While Rolnick laid the research-policy advocacy foundation in 2003, Wozniak says, Neel has really turbocharged this environment. Recently, Wozniak led development of a framework for gathering Covid-19-related data, so public and business leaders would have good information and analysis for making decisions during the pandemic.

    Alene Tchourumoff, the Minneapolis Feds senior vice president of community development and engagement, says she and other leaders have emphasized spending time in Upper Midwest communities to learn about peoples concerns. Before Covid-19 curtailed travel, key themes emerged.

    Almost everywhere we go in the Ninth District, people talk about housing, Tchourumoff says. They talk about access to child care, they talk about health care. The Fed wants to identify the stress points for low- and moderate-income people, she adds, so they can conduct research, develop solutions and move toward an economy that works for everybody.

    That egalitarian approach is highlighted in the spring 2020 premiere issue ofFor All, a magazine of the Opportunity & Inclusive Growth Institute. The traditional view among central bankers is that theres little we canor shoulddo about economic opportunity and inclusive growth, Kashkari wrote in a column. He favors reexamining that assumption. We need to look beyond averages to see what effect national policies have on different groups.

    Housing costs have been rising at a much faster rate than incomes, so the Opportunity & Inclusive Growth Institute convened a conference last fall to discuss research and affordability options.

    You cant tax the middle class to subsidize the middle class, because that doesnt make sense, Kashkari says. So somehow we have to unlock the private sector to come in at much bigger scale to build more supply. Thats the only way were going to make things more affordable for the majority of people.

    From Kashkaris perspective, he is shaping a Minneapolis Fed that will be highly relevant to policymakers, will garner the publics trust, and will help improve the lives of people who struggle financially.

    Hes not afraid of critics, which is why hes pleased the Fed made a commitment to the city of Minneapolis to research the impact of the $15 minimum wage. Minneapolis told us that we were the one research group that everybody trusted would do the analysis honestly, both the business community and the activist community, Kashkari says.

    Are we going to be taking some risk that we might be upsetting people? Yeah, but this is exactly the kind of research we should be doing, Kashkari concludes.

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    The Minneapolis Fed sheds its reserve - MinnPost

    Fire Force Sheds Light on a DANGEROUS Theory | CBR – CBR – Comic Book Resources - September 11, 2020 by Mr HomeBuilder

    Fire Force's investigation into the Great Cataclysm closes with explosive action and some dangerous revelations.

    WARNING: The following contains spoilers for Season 2, Episode 10 of Fire Force, "The Woman in Black," now streaming on Crunchyroll.

    Fire Forcecloses its investigation into the Great Cataclysm and uncovers more details about the menacing Evangelist, as Shinra's battle with Tempe hits breakneck speeds.As Shinra and the Woman in Black share an Adolla Link, the two discuss the Woman's past and the longstanding danger that the Evangelist and her plan pose to the world.

    With Tempe and Ogun still duking it out and the Woman in Black's time running short, she grants Shinra one second of Adolla Grace to help him defeat the demon and preserve the forest. Shinra has achieved this Grace once before during his fight against his little brother Sho, and implements it with a similar effect here as he reaches incredible speeds.

    RELATED: Fire Force's Ogun Debuts His SCORCHING Flamy Ink Ability

    With the Adolla Grace, Shinra's body travels so fast it's broken down to the particle level, allowing him to travelquickerthan the speed of light, affecting the flow of time. When Shinra strikes Tempe with his time-bending kick, the young hero gets a glimpse into the demon Infernals memoriesfrom when he was still human. Tempe wanders through the desert afterthe Great Cataclysm claimed his wealth and family until reaching a spatial rift, which acts as an invisible barrier thathe can't pass through. Suddenly, the Evangelistemerges from the other side of the rift, towering over Tempe.

    Tempe grovels at the Evangelist's feet, believing her to be God, and begs for the type of joy his money and status brought him. With a menacing smile, the Evangelist unleashes one of her insects, which imbeds itself into Tempe's chest, turning him into an Infernal. Back in the present-day, Shinra asks the Woman in Black if she, like the Evangelist, came from the Adolla world too since he senses a similarity between them. However, the Woman in Black states she was initially a human enkindled with an Adolla Burst from the Evangelist's insects.

    Shinra and the Special Fire Force know that the Evangelist is working behind the scenes to reach her goal of engulfing the world in flames with a new Great Cataclysm. She has been orchestrating it since at least the first cataclysm over 250 years ago, but the Woman in Black reveals things could have been set in motion much earlier than that. The Evangelist may have been manipulating humanity since ancient times, constructing various "Gods" to pull the strings of history.

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    Fire Force Sheds Light on a DANGEROUS Theory | CBR - CBR - Comic Book Resources

    Hans Op de Beecks Garden of Whispers art installation sheds light on the refugee crisis – Hindustan Times - September 11, 2020 by Mr HomeBuilder

    A renowned Belgian artist by the name of Hans Op de Beeck created a quintessentially site-specific work of art in the 13-century gothic church of the Convent of the Jacobins, in Toulouse, France. Created for the Printemps de Septembre Festival, this multi-sensory, immersive art installation is called The Garden of Whispers.

    The 600 square metres of space has been re-imagined as a type of wasteland, where the terrain has been changed to sand dunes and lifeless trees. The sand used by Op de Beeck matches the same ochre colour of the buildings centuries-old brick walls. A wooden walkway winds through the sand dunes, lit only by a simple string of lights.

    As you walk through the desolate landscape, whispers emerge from the sand all around you through 20 carefully concealed speakers, sharing secrets, confessions- of misdeeds and escapades. Women, men and children, all seem to be reaching out of the atmosphere to express themselves. The voices present in a mangled form, overlapping one another.

    The area represents a kind of abandonment one feels while walking through an area which was previously occupied but has since been deserted, left to those who themselves are forgotten. While walking through the area, one can spot small makeshift campsites, cobbled together from scraps of canvas and wooden poles, according to the artists website, which serve as a visual reminder of the shelters built by nomads in the desert.

    According to the artist, Hans Op de Beeck, this installation serves as an embodiment of man as a being who stages the world around him in a tragi-comic way, as told in an interview with The Mind Circle. The Garden of Whispers employs a range of biblical and mystical references that touch on the issue of refugees. The visuals and the whispers of the installation create an atmosphere that is almost confessional in nature, but further than that, the artist leaves the installing to the interpretation of the viewers introspection.

    More so, with the current world environment, the sense of desolation created by Hans Op de Beeck, is even more relevant as the conversation regarding this post-apocalyptic pandemic has become the new norm.

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    Hans Op de Beecks Garden of Whispers art installation sheds light on the refugee crisis - Hindustan Times

    Iggy Azalea Sheds Off Baby Weight With Her Recent Stunning Photo – TheThings - September 11, 2020 by Mr HomeBuilder

    In three short months, not only did Iggy managed to shed the baby weight, but shows off in a glamorous picture on her Instagram.

    Australian rapper Iggy Azalea's time with 2020 was quite a whirlwind. Not only will she have a third album out sometime before the end of this year, but she also became a mother to a baby boy namedOnyx Carter with 23-year-old rapper Playboi Carti as the father. She has been keeping her private life secretive buthas been seen inphotoswith her son here and there. In three short months, not only did Iggy managed to shed the baby weight, but shows off in a glamorous picture on her Instagram.

    Related:10 Things We Just Learned About Iggy Azalea

    We don't know what fitness program she took part in to obtain her hourglass figure back, but Iggy definitely looked as if she never carried a baby to begin with. Fans are not only mesmerized by how gorgeous she looks, but how she manages to do so after three short months of giving birth to her son. The fact that her photos hid her pregnancy so well shows that Iggy dedicates time to be on social media while also prepping for motherhood. So what's the secret, Iggy?

    Next:Heres Why Iggy Azalea Hid Her Pregnancy From Fans

    Khloe Kardashian 'Likes' Comment Blaming Kourtney Kardashian For 'KUWTK' Demise

    Marianne is a freelance writer who graduated with a Bachelor's degree in English. Along with working for TheThings, she has contributed to Valnet's sister sites TheGamer and GameRant, as well as other sites including FanSided's App Trigger and GAMURS group Gamepur. During her spare time, she loves going to the arcade to play rhythm games, play Nintendo games such as Fire Emblem and Pokmon, and catch up on manga and novels.

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    Iggy Azalea Sheds Off Baby Weight With Her Recent Stunning Photo - TheThings

    New Research in JNCCN Sheds Light on Multi-Organ Adverse Events from Immunotherapy – PRNewswire - September 11, 2020 by Mr HomeBuilder

    PLYMOUTH MEETING, Pa., Sept. 8, 2020 /PRNewswire/ --New international research in the September 2020 issue of JNCCNJournal of the National Comprehensive Cancer Networkadds important knowledge about how immunotherapy-related adverse events (irAEs) can impact more than one organ in a single patient. This study provides new information on how frequently multiple organ side effects occur, and reveals that multi-organ irAEs are more likely to happen sequentially rather than simultaneously.

    "Multi-organ irAEs are under-recognized, under reported, and their pathophysiology is poorly understood," said lead researcher Ganessan Kichenadasse, MBBS, FRACP, Flinders Centre for Innovation in Cancer, Flinders University, in Bedford Park, Australia. "We need a concerted international effort to improve our understanding and help identify predisposing factors and prevention strategies. Treating teams should be aware of the potential for irAEs which affect multiple organs and institute plans for recognizing and managing them."

    The researchers evaluated the incidence and patterns of multi-organ irAEs using individual patient data from four non-small cell lung cancer trials where patients were treated with atezolizumab, a PD-L1 inhibitor. Those four studies, known as OAK, POPLAR, BIRCH, and FIR, include investigators from around the world. Out of 1,548 patients worldwide, 27% experienced at least one adverse event; 5.4% experienced multi-organ irAEs. Skin, laboratory, endocrine, neurologic and pulmonary abnormalities represented the most common organ systems involved.

    Among the 84 cases with multi-organ irAEs, 70 patients (83.3%) had two organ systems affected, 13 (15.5%) had three, and one patient had four systems affected. 86% of multi-organ irAE patients experienced these side-effects sequentially rather than concurrently. According to the results, multi-organ irAEs were generally amenable to satisfactory management, and their occurrence was associated with better overall survival rates.

    "Based on the mechanisms of action for these immune checkpoint agents, tumor response and irAEs are likely to have a common pathophysiology," said Dr. Kichenadasse. "There is also probably a cumulative immune activation with every dose of immunotherapy, meaning lengthier treatment could lead to both better survival and added organ damage. However, it is important to highlight that this analysis was exploratory and hypothesis generating; these results need to be confirmed through additional research."

    "This study confirms that more than one organ, at the same time or sequentially, can be affected by immune-related adverse events from checkpoint inhibitor therapy," commented Igor Puzanov, MD, MSci, FACP,Professor of Medicine, Director of the Early Phase Clinical Trials Program and Chief of Melanoma at Roswell Park Comprehensive Cancer Center, who was not involved in this study. "This is worth noting for all practicing oncologists and other specialists taking care of patients who are receiving these therapies. The silver lining here is the seemingly improved overall survival we see among these patients."

    To read the entire study and a related commentary, visit JNCCN.org. Complimentary access to "Multiorgan Immune-Related Adverse Events During Treatment With Atezolizumab" and "Immune Related Adverse Events: Implications for Immune Checkpoint Inhibitor Therapy" is available until December 10, 2020.

    JNCCN Impact Factor Reaches New Record

    The impact factor for JNCCN has risen from 7.570 to 9.316. It now ranks 21 out of 244 oncology journals measured, and in the top quartile for all medical journals worldwide. According to Clarivate Analytics, research published in JNCCN was cited a total of 2,534 times in 2017 and 2018.

    AboutJNCCNJournal of the National Comprehensive Cancer NetworkMore than 25,000 oncologists and other cancer care professionals across the United States readJNCCNJournal of the National Comprehensive Cancer Network. This peer-reviewed, indexed medical journal provides the latest information about innovation in translational medicine, and scientific studies related to oncology health services research, including quality care and value, bioethics, comparative and cost effectiveness, public policy, and interventional research on supportive care and survivorship.JNCCNfeatures updates on the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines), review articles elaborating on guidelines recommendations, health services research, and case reports highlighting molecular insights in patient care.JNCCNis published by Harborside. VisitJNCCN.org. To inquire if you are eligible for aFREEsubscription toJNCCN, visithttp://www.nccn.org/jnccn/subscribe.aspx. Follow JNCCN on Twitter @JNCCN.

    About the National Comprehensive Cancer NetworkThe National Comprehensive Cancer Network (NCCN) is a not-for-profit alliance of leading cancer centers devoted to patient care, research, and education. NCCN is dedicated to improving and facilitating quality, effective, efficient, and accessible cancer care so patients can live better lives. The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) provide transparent, evidence-based, expert consensus recommendations for cancer treatment, prevention, and supportive services; they are the recognized standard for clinical direction and policy in cancer management and the most thorough and frequently-updated clinical practice guidelines available in any area of medicine. The NCCN Guidelines for Patients provide expert cancer treatment information to inform and empower patients and caregivers, through support from the NCCN Foundation. NCCN also advances continuing education, global initiatives, policy, and research collaboration and publication in oncology. Visit NCCN.org for more information and follow NCCN on Facebook @NCCNorg, Instagram @NCCNorg, and Twitter @NCCN.

    Media Contact: Rachel Darwin267-622-6624[emailprotected]

    SOURCE National Comprehensive Cancer Network

    http://www.jnccn.org

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    New Research in JNCCN Sheds Light on Multi-Organ Adverse Events from Immunotherapy - PRNewswire

    The Shed to Reopen on October 16 with Solo Exhibition by Howardena Pindell – ArtfixDaily - September 11, 2020 by Mr HomeBuilder

    New York's The Shed debuted in April 2019 in a grand $475 million building in Hudson Yards. After being closed for over six months, this new arts center plans to reopen with a powerful presentation of works by Howardena Pindell.

    The Shed has announced that it will reopen on Friday, October 16, with the new solo exhibition Howardena Pindell: Rope/Fire/Water, examining the violent, historical trauma of racism in America and the therapeutic power of artistic creation. After closing on March 13 in response to New York Citys efforts to contain the spread of COVID-19, The Shed will welcome back visitors, Thursdays through Sundays, with enhanced health and safety protocols, as well as free admission to the exhibition through October 31.

    Howardena Pindellphoto: Nathan Keay

    We are very honored to produce and present Howardena Pindells powerful and timely work as our reopening exhibition this fall, and to have commissioned her unrealized project of 50 years, Rope/Fire/Water. When we started planning an exhibition with Pindell in 2017, we could not have foreseen its resonance with this summers profound call to dismantle systemic racism and to establish equality for Black lives, said Alex Poots, The Sheds Artistic Director and CEO. Were so pleased to welcome our audiences and neighbors back to The Shed after closing our doors in March, less than a year after opening, and weve implemented thorough protocols to ensure a safe environment for all. As our city restarts, we continue in our commitment to supporting artists and providing a space where they can address the urgent issues of our time.

    Howardena Pindell: Rope/Fire/Water presents Pindells first video work in 25 years, as well as new large-scale paintings, and several abstract paintings from earlier in her career.

    Over her nearly 60-year career, Pindell has created richly textured abstract paintings while engaging with politics and the social issues of her time. The powerful new video Rope/Fire/Water, commissioned by The Shed, is a work that Pindell has wanted to create since the 1970s, inspired by a traumatic experience in her youth when she saw a shocking image of racial violence.

    Pindell also will also debut a pair of large-scale paintings related to global atrocities of imperialism and white supremacy, and several abstract paintings that demonstrate a through line in Pindells practice: after working on traumatic historical projects, the artist decompresses by creating meticulously produced, large-scale abstract works on unstretched canvas.

    An online gallery of paintings in the exhibition with explanatory texts and a digital reading room of supplementary resources will be available online at theshed.org. Additional programs exploring themes of the exhibition will be announced.

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    The Shed to Reopen on October 16 with Solo Exhibition by Howardena Pindell - ArtfixDaily

    Productivity profiling sheds light on how people get the job done – The Irish Times - September 11, 2020 by Mr HomeBuilder

    Companies have been using personality profiling to get insights into their employees for decades, but now UK-based productivity specialists Smarter Not Harder has developed an online tool that profiles productivity traits. It is called PQ (productivity quotient) and if you have ever wondered what drives your productivity or that of the people on your team theres now a 15-minute test that can tell you.

    Ive probably done 10,000 or more productivity-related interviews in my career, and Ive reached a point where, within a few minutes of starting to talk to someone, I know exactly what their productivity traits are going to be, says company co-founder Neil Massa.

    Just over two years ago I mentioned this to Cliff Edwards, who is both a business psychologist and a mathematician, and he reckoned he could model it and create an algorithm around it. He spoke to other members of our team who have also done thousands of similar interviews, and the result is PQ, a mathematical model that enables us to predict what peoples preferences will be when it comes to managing their time and productivity.

    Massa says peoples productivity behaviour is driven by numerous factors, including the beliefs and attitudes they have formed over time, the characteristics they were born with and their expectations of work and life.

    What the profiling does is to help them understand what their preferences mean in practice, while also shedding light on why different styles may be the reason a team is faltering or its members are not getting on.

    Preferences are grouped under four productivity pillars: logical; instinctive; self; and team.

    Massa says that people with a high logical preference typically love spreadsheets, lists, gadgets and technology that automates things. They get their productivity from being incredibly logical and organised which I stress is not for everyone, he says.

    Those with an instinctive preference go a little more on emotion. They trust their intuition, and quite often make complex decisions involving a lot of information in a very short space of time and sometimes this freaks out their colleagues. Theyre incredibly valuable people, partly because of their creativity but also because of the speed with which they can arrive at their decisions and take action.

    The logical and the instinctive could be seen as polar opposites, but its not inconceivable that someone could have a balance of both.

    The productivity of those operating from the self pillar is driven by what is important to them, and this has its good and bad points. On the negative side, they can come across as selfish, but Massa says this is often because they are gimlet-like in focus. They dont do anything they dont need to do, and usually have very clear priorities, goals and objectives.

    Productivity linked to the team pillar is someone who can see the value in the people they work with, and uses it to help them achieve what they need to achieve, Massa says. So this type of person will call on and draw in the experiences and talents of other people to get work done.

    Theyre also very good at enabling other people. For example, they will consider whether something they might do will get in the way of someone else doing their job. They are collaborative and embrace team working holistically.

    PQ profiling takes 15 minutes online. When it was being designed Massa stipulated that it should be quick and not something you need a flask of coffee, two Kit Kats and 45 minutes or more to do, he says.

    When someone takes a profile it gives them their relative scores and preferences across the four pillars ,and tells them a little bit about how this might manifest itself in the way they approach things.

    Individuals can take the test for 95 (106) and there are different packages for corporate clients that include additional elements such as coaching.

    Apart from throwing light on peoples individual productivity drivers the profiling can also be useful in starting wider conversations around how teams tick.

    The power of the tool lies in the insights and what you do with them, Massa says. Were just beginning a project with a technology company that had to restructure due to the lockdown. They had to put together new teams made up of people starting work for the first time and those who havent worked remotely before. They are using the tool both to understand individuals and maximise team productivity.

    While PQ profiling will indicate someones preferred route to productivity Massa says context can affect behaviour.

    If someone is in a steady state their default preferences will apply. However, they can shift and if youre in a period of change, such as has happened during the lockdown, an individual may lean on one more than the other. Ive taken the test quite a few times, and its picked up subtleties and nuances around the circumstances Ive been in when Ive taken it. Preferences are not fixed forever.

    If youre running a team you ideally need people with all four pillar traits, Massa adds. Its also really important that people understand the preferences of those around them.

    Most people dont set out to make life difficult for others. They do it accidentally, and if they knew why there would be a lot more harmony and higher levels of productivity.

    Originally posted here:
    Productivity profiling sheds light on how people get the job done - The Irish Times

    Shed Design Software market is expected to pick up in healthy CAGR by 2020-2025 Top companies | Chief Architect, Shed Boss, Fair Dinkum Sheds,… - September 11, 2020 by Mr HomeBuilder

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    Shed Design Software market is expected to pick up in healthy CAGR by 2020-2025 Top companies | Chief Architect, Shed Boss, Fair Dinkum Sheds,...

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