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Mother Mary sheds tears of blood in Srikakulam | Studio N
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Eskom Spokesperson sheds light on load-shedding situation
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A class of drug for treating arthritis -- all but shelved over fears about side effects -- may be given a new lease of life, following the discovery of a possible way to identify which patients should avoid using it.
The new study, led by Imperial College London and published in the journal Circulation, sheds new light on the 10-year-old question of how COX-2 inhibitors -- a type of non-steroidal anti-inflammatory drug (NSAID) -- can increase the risk of heart attack in some people.
NSAIDs -- which include very familiar drugs such as ibuprofen, diclofenac and aspirin -- are widely-used treatments for debilitating inflammatory conditions such as arthritis as well as being used for general pain relief worldwide. NSAIDs are also being investigated for their potential to prevent cancer. COX-2 inhibitors, which include Vioxx and Celebrex, were developed in the 1990s to avoid the risk of stomach ulcers caused by some NSAIDs, but after they were linked to an increased risk of heart attacks, they rapidly fell out of favour and some brands, including Vioxx, were withdrawn.
The new study, in mice and human volunteers, was led by Professor Jane Mitchell and Dr James Leiper. Professor Mitchell, from the National Heart and Lung Institute at Imperial, said: "Although the majority of arthritis sufferers could safely use COX-2 inhibitors, the fear of heart attacks has left some patients confused and worried about their medication and GPs nervous about prescribing them. This problem is made worse because we now know that most NSAIDs, not just COX-2 selective drugs, carry a similar risk of heart attacks in some patients.
"If we could identify which people have an increased risk, these patients could be offered more appropriate treatments -- and we can start to look at ways of reducing or averting the risk entirely."
NSAIDs work by preventing the production of prostaglandins -- the chemical messengers in tissues and joints that trigger pain and inflammation. Prostaglandins are produced by two different enzymes, known as COX-1 and COX-2, which are found at sites of inflammation as well as in other sites around the body.
The study, funded by the Wellcome Trust, the British Heart Foundation and the Medical Research Council (MRC), looked at where and how removing COX-2 caused changes in gene activity in mice. They found that knocking out COX-2 caused changes in three genes in the kidney which predicted a rise in levels of a molecule linked to cardiovascular disease, called ADMA. In subsequent tests, the researchers found that taking NSAIDs led to a rise in ADMA levels in mice and in 16 human volunteers.
Dr James Leiper, from the MRC Clinical Sciences Centre at Imperial, said: ''ADMA is an independent risk factor for cardiovascular disease. In people increases of ADMA similar to those we found are linked with significant increases in cardiovascular disease and death. Our discovery that COX-2 inhibitors raise ADMA levels provides a plausible mechanism for the increased cardiovascular risk associated with these drugs and provides insights into how this risk might be mitigated'
Professor Mitchell thinks that higher ADMA levels might work as an indicator of which patients are at greater risk of a heart attack.
"If we are right," said Professor Mitchell, "ADMA could be used as a biomarker in a simple blood test to identify who may be at risk, and regular screening would allow GPs to monitor patients' ADMA levels to ensure these remain within safe limits whilst taking the drug." The team are planning a clinical trial to test their idea.
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Biomarker discovery sheds new light on heart attack risk of arthritis drugs
The oceans are a mystery in more ways than one, but you might not expect the answers to come from a pack of electronics and a comet. But that's what the European Space Agency (ESA) says about the unmanned Rosetta probe orbiting comet 67P/ChuryumovGerasimenko. Though 67P is making its first visit to the inner Solar System and won't come closer to the Earth than hundreds of millions of miles, it is throwing new light on one of the fundamental questions in Earth's history: Where did the oceans come from?
According to current theories, the Earth was formed as the disk of dust and gas that surrounded the primordial Sun coalesced into planets. The water in the oceans could have come from that, but the formation of the newborn Earth 4.6 billion years ago left it an incandescent molten mass that would have boiled away any water into space before the crust even had a chance to form. And yet, today three quarters of the Earth is covered by water. So, what was the source?
One idea is that the water came from comets. It's a logical source. Comets are "dirty snowballs" made up largely of ice, so a steady rain of them during the early history of the Earth when the planet was being bombarded by objects from space could have been the origin of the oceans. However, proof needs more than plausibility; it needs evidence.
To see if comets could have been the source of Earth's water, scientist's turned to isotopic analysis. Water is made up of an oxygen atom and two hydrogen atoms, and the hydrogen atoms are made of a proton and an electron. However, if a hydrogen atom also has a neutron in its nucleus, it becomes a hydrogen isotope called deuterium.
What's clever about this is that the ratio between normal hydrogen atoms and deuterium isn't fixed. It depends on the origin of the atoms, and by matching the ratios of one source against another, scientists can deduce where the water in any particular part of the Solar System probably came from because the ratio changes the farther away from the Sun you get. This means that water that comes from the Asteroid Belt between Mars and Jupiter will be different from that coming from the Kuiper Belt beyond Pluto, which will in turn differ from that of the Oort cloud on the fringes of the system.
This is where Rosetta comes in. Among the suite of instruments carried by the orbiter is the Rosetta Orbiter Spectrometer for Ion and Neutral Analysis (ROSINA), which is a pair of mass spectrometers and a pressure sensor used to determine the chemical composition of comet 67P's coma, the temperature and speed of the gas molecules, and last, but not least, the ratio of various isotopes including hydrogen.
According to astronomers, comet 67P is a fossil of the earliest days of the Solar System because it came from the Oort cloud, which has remained unchanged for billions of years. These icy fragments float in space until a passing star or other massive object disturbs them and sends them hurtling toward the Sun. As they do so, some are captured by the gravitational pull of Jupiter and swung into new orbits. In the case of 67P, it now swings around the Sun in an elliptical orbit with a period of 6.5 years, coming no closer to the Sun than a point between Earth and Mars before heading back out beyond Jupiter.
What all this means is that 67P is made up of very ancient water and if comets are the source of Earth's oceans, then the isotope ratios should match to a reasonable degree. However, they don't. ESA says the 67P confirms measurements taken of 11 other comets that have been studied all of which, except one, showed very different deuterium/hydrogen ratios from that of Earth. And the odd-comet out, called comet Hartley 2, is a Jupiter Family comet, which has a different origin from those in the Oort cloud.
Deuterium-to-hydrogen ratios in the Solar System (Image: ESA/Altweg)
In all, ESA says that the deuterium/hydrogen ratio of the Earth is 1.56 104 while 67P's ratio is 5.3 x 104. This makes 67P's ratio three times higher than that of Earth's oceans and is higher than that of any other Oort cloud comet measured so far.
FREDERICK Peralta with son Kevin. JILSON SECKLER TIU
Getting teary-eyed is perhaps the last thing one expects to experience after watching a Frederick Peralta fashion show.
Known for theatrical and heavily embellished pieces, the multi-awarded designer seems more likely to shock his audience than make it cry.
However, this wasnt the case recently as Peralta staged Marry Me at Marriott, his 30th anniversary show featuring 34 wedding gowns and a dozen tuxedos.
There wasnt a dry eye in the grand ballroom as he and his 22-year-old son Kevin Peralta, one of the shows models, walked down the ramp at the end of the show, holding hands and acknowledging the hearty applause.
Those familiar with the designers story and how Kevin came into his life savored the rare moment.
That night wasnt exactly Kevins modeling debut for his dad. But it was the first time many people, including some of Peraltas friends and clients, saw how Kevin had grown.
The first time he modeled for me was when he turned four, said Peralta. He was a ring bearer in my Paco Park show. When he was 12, he also took part in a wedding show I did at Edsa Shangri-La.
The designer asked Kevin, whom he adopted as a baby, to do it as a favor for Papa.
The young man, who grew up surrounded by his fathers dresses, loyal clients and team of dressmakers in Malate, readily obliged.
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Frederick Peralta sheds a tear
December 9, 2014 6:40 AM
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GROSSE POINTE PARK (AP) - Officials say farmers market sheds that block a roadway between the poverty-pocked east side of Detroit and upscale Grosse Pointe Park arent expected to be removed anytime soon.
The cities mayors in October reached an agreement to remove the sheds, which some say were erected as a hostile act.
Grosse Pointe Park City Council heard comments on the issue Monday night, according to the Detroit Free Press. City Councilman David Clark says the blockade will eventually come down or at least change its form, but its not going to be soon.
The deal includes removing blight and redeveloping the border area between the two cities to create a connecting gateway. Grosse Pointe Park will reopen drivers access to the blocked off Kercheval Avenue, where workers finished building traffic barriers and sheds earlier this year.
Detroit Land Bank Authority spokesman Craig Fahle told officials Monday that Detroit is taking rapid action against blighted properties on the Detroit side of the border.
Grosse Pointe Park City Attorney Dennis Levasseur says the community is negotiating with Detroit about a comprehensive development on Kercheval.
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Grosse Pointe Park Barricade Staying Put For Now