This event is both ONLINE and IN-PERSON with very limited seating.

It's been awhile, and we are thrilled to be hosting our first remodeling seminar since the pandemic. We will be combining some of the greatest attributes of our traditional seminars with some exciting new concepts, and we hope to make this presentation even more special for our attendees and online audience.

Here is what our in-person attendees will receive:

- Live Q and A with our panel of expert home builders and designers with subjects tailored to your specific home makeover.

- Reserved seating with dinner served brown bag-style at your seat.

- Complimentary drinks, such as beer, wine, bottled water, and coffee.

- A VIP swag bag of goodies to take home.

- A chance to win a fantastic door prize.

We want you to feel safe and comfortable and able to learn about your remodel options. We are limiting the in-person seating to just 20 attendees to allow for distancing and ample private side table seating. Guests must pre-register for the in-person event and agree to a few short statements of health prior to the day of the seminar. We ask that masks be worn upon entrance to the showroom until you are seated at your reserved seat (we will provide you with a mask, if you do not have one of your own). We will also provide you with hand sanitizer at your table. Each in-person attendee must be symptom free of any COVID-19 symptoms, and to that effect, we will be doing contactless temperature checks of each individual upon arrival.

You may also register to watch online from the comfort of your own home.

We look forward to seeing you very soon as we work to make your house the home of your dreams!

URL:

Tickets: https://go.evvnt.com/696153-0?pid=4509

Price:

VIP In Person: USD 15.00

Category: Attractions | Talks and Lectures

Time: 6:30 pm to 8:30 pm

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Local Event: Home Remodeling: 101 (VIP in-person or live streaming options) - Patch.com

Muscular pulmonary artery and annexed bronchus: GLA (red outline) = great longitudinal axis; ED (green outline) = external diameter; EP (yellow outline) = external perimeter; IP* (blue outline) = internal perimeter; LP (pink outline) = lumen perimeter; TA (within yellow outline) = total area; IA* (within blue outline) = internal area; LA (within pink outline) = lumen area. https://doi.org/10.1371/journal.pone.0239561.g001

Severe asthma in horses can trigger thickening of the walls of lung arteries, researchers have found.

This kind of remodeling is also seen in the pulmonary arteries of humans with chronic obstructive pulmonary disease, which contributes to the development of pulmonary hypertension.

Similar changes to the pulmonary arteries have also been seen in rodent experiments as a result of allergic airway inflammation.

Severe equine asthma, also known as heaves and recurrent airway obstruction, is a chronic, non-infectious inflammatory lower airway disease. It is characterized by recurrent episodes of airway obstruction caused by exposure to environmental antigens, such as fungi, hay mites and endotoxins.

Serena Ceriotti and her colleagues, reporting in the open-access journal PLOS ONE, note that pulmonary hypertension and changes to the function of the right ventricle of the heart are complications of severe equine asthma, arising from pulmonary hypoxic vasoconstriction.

However, as pulmonary hypertension is only partially reversible by giving oxygen, other factors are likely involved.

The study team set out to investigate the presence of changes to the pulmonary arteries in cases of severe equine asthma and their distribution throughout the lungs. They also examined the potential reversibility of this remodeling either through long-term avoidance of the allergens that trigger the condition, or inhaled corticosteroids.

The researchers measured the total wall area of pulmonary arteries from different regions of the lungs of asthmatic horses and compared the results with those from healthy control horses. The smooth muscle mass of pulmonary arteries was also estimated.

Reversibility of changes to the blood vessels in asthmatic horses was assessed after a year of avoiding the allergens alone, or treatment with inhaled fluticasone for a similar time.

The scientists found that the pulmonary arteries showed increased wall area in the apical (upper reaches) and in the caudodorsal (closest to the spine, toward the tail) lung regions of asthmatic horses in both exacerbation and remission.

The pulmonary artery smooth muscle mass was similarly increased.

Both treatments reversed the increase in wall area, they reported. However, a trend for normalization of the vascular smooth muscle mass was observed only after treatment with antigen avoidance, but not with fluticasone.

In conclusion, severe equine asthma is associated with remodeling (thickening) of the pulmonary arteries consisting of an increased smooth muscle mass.

The resulting narrowing of the artery could enhance hypoxic vasoconstriction, contributing to pulmonary hypertension, they said.

In our study population, the antigen avoidance strategy appeared more promising than inhaled corticosteroids in controlling vascular remodeling.

However, further studies are needed to support the reversibility of vascular smooth muscle mass remodeling after asthma treatment.

Discussing their findings, the researchers said their work revealed significant pulmonary artery wall thickening in asthmatic horses compared to controls.

The average wall area of muscular pulmonary arteries in asthmatic horses was 7% to 12% greater than that of controls increases similar to those seen in humans with chronic obstructive pulmonary disease.

This remodeling affected only the caudodorsal lung fields and the lung apex, they said.

An increase in airway smooth muscle mass was also present in severely asthmatic horses, they said.

Short-term antigen avoidance significantly improved lung function and airway inflammation in asthmatic horses, while smooth muscle mass was not reduced in muscular pulmonary arteries in the present study, nor in small peripheral airways in a previous work.

While pulmonary artery wall thickening was reversed by long-term antigen avoidance (12 months), this was not the case for horses treated that inhaled corticosteroids for the same period, despite six months of associated antigen avoidance.

While inhaled corticosteroids were mainly effective on airway obstruction, long-term antigen avoidance better controlled neutrophilic airway inflammation.

This, they said, supports a possible role of inflammation in the development of pulmonary artery remodeling, facilitated by the strict anatomic relationship between pulmonary circulation and the airways, as already investigated in acute allergic human asthma.

The researchers say further studies should focus on the role of hypoxemia and inflammation in inducing remodeling of pulmonary arteries smooth muscle, as well as its impact on pulmonary artery pressure and cardiovascular complications in severe equine asthma.

The full study team comprised Ceriotti, who is Auburn University in Alabama; Michela Bullone, Mathilde Leclere and Jean-Pierre Lavoie, who are with the University of Montreal in Quebec; and Francesco Ferrucci, who is with the University of Milan in Italy.

Ceriotti S, Bullone M, Leclere M, Ferrucci F, Lavoie J-P (2020) Severe asthma is associated with a remodeling of the pulmonary arteries in horses. PLoS ONE 15(10): e0239561. https://doi.org/10.1371/journal.pone.0239561

The study, published under a Creative Commons License, can be read here.

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Thickening of arterial walls in the lungs of badly asthmatic horses seen in study - Horsetalk

Construction-industry veteran Rebecca Fountain founded general contracting firm KOR Building Group in 2013 with a focus on residential renovations, government contracting, hotel remodels and commercial construction. Perhaps of equal importance, Fountain built KOR on a foundation of inclusivity and diversity.

In an industry that is traditionally male-dominated, KOR is among one of the few construction firms recognized as a WBENC-certified Woman-Owned Business and has achieved additional certifications including DBE, ESB, SBE, WBE and WOSB. The company is committed to working with diverse subcontractors, suppliers and professional service firms, and has received local and regional acclaim for its work on behalf of clients such as The Venetian, The Palazzo and Excalibur, as well as projects at McCarran International Airport for the Department of Aviation, Southwest Airlines, United Airlines, Hudson News and Jamba Juice.

KOR completed 29 tenant improvement and remodeling projects in the last year, including with the TSA on its Defense Priority Allocation System at McCarran Airport, and design and planning within the Excalibur Food Court with the Feel Good Brands corporation.

In the community, KORs charitable contributions include construction support and material donations for local nonprofits Veterans Village and the Las Vegas Rescue Mission.

Original post:
Contractor of the Year Awards: Diverse General Contractor of the Year, KOR Building Group - Las Vegas Sun

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100 years ago

Sept. 21, 1920: Local businesses are spending almost $3 million on construction and remodeling this year. The Consistory building is still the biggest project at $600,000. Next is the Lafayette Apartments at $300,000. (The Lafayette is only project still serving its original purpose.)

75 years ago

Sept. 21, 1945: From the now it can be told file: The Sylvania plant in Bloomington made contributions to Britains radar program by making tubes the British couldnt. Other tubes were used against Japan in missile nose cones, making the missiles explode as they near their targets.

50 years ago

Sept. 21, 1970: Work crews are setting up a prefabricated portable classroom at Raymond School on the west side. Its a step to ease overcrowding but it wont have toilet facilities. Remedial reading and resource programs will be housed there.

25 years ago

Sept. 21, 1995: Danny Tomlinson of Gibson City was convicted of beating up Saybrook Police Chief Madeline Nickum. She had stopped him on suspicion of DUI. Tomlinson, 44, faces a 10-year sentence and possibly more. The chief is still suffering after-effects of her injuries.

Compiled by Jack Keefe; jkeefe@coldwellhomes.com.

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100 years ago: $3 million in construction, remodeling set - Bloomington Pantagraph

Androgen deprivation therapy (ADT) is a cornerstone treatment for locally advanced or metastatic prostate cancer (PCa). However, its potential effects on the tumor immune microenvironment (TIM) of PCa patients and the underlying mechanism remain largely unclear. To explore the effects of ADT on PCa TIM, RNA sequencing was performed on six paired pre-ADT biopsy and post-ADT PCa lesions, and five paired paracancerous benign tissues from patients receiving neoadjuvant ADT with locally advanced PCa. Bioinformatics methods including ESTIMATE and ssGSEA were used to evaluate the stromal immune score and immune cell infiltration in PCa and paracancerous tissues. Weighted correlation network analysis was used to screen hub genes in the ADT-induced immune remodeling process. The results showed differences exist between PCa and paracancerous tissues in response to ADT. Compared with paracancerous tissues, the immune remodeling effect of ADT in PCa was more intense. ZFP36, JUNB, and SOCS3 served as hub genes in the ADT-induced immune remodeling process and were associated with PSA recurrent-free survival in the TCGA and our neoadjuvant ADT cohort. To investigate the joint action of the above three hub genes, an immune signature score was constructed. The results showed that immune signature score-based immune subtypes reveal the heterogeneity of the immune microenvironment of PCa and showed significant differences in patient prognosis, tumor immune infiltration, mutation burden, and landscape.

Cell death & disease. 2020 Sep 19*** epublish ***

Xingbo Long, Huimin Hou, Xuan Wang, Shengjie Liu, Tongxiang Diao, Shicong Lai, Maolin Hu, Shengqi Zhang, Ming Liu, Hong Zhang

Department of Urology, Beijing Hospital, National Center of Gerontology, No 1, Dongdan Dahua Road, Dongcheng District, Beijing, 100730, China., Graduate School of Chinese Academy of Medical Science and Peking Union Medical College, No. 9, Dongdan Sanjiao Alley, Dongcheng District, Beijing, 100001, China., Department of Urology, Beijing Hospital, National Center of Gerontology, No 1, Dongdan Dahua Road, Dongcheng District, Beijing, 100730, China. ., Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Peking University Health Science Center, Beijing, 100191, China. .

PubMed http://www.ncbi.nlm.nih.gov/pubmed/32951005

Originally posted here:
Immune signature driven by ADT-induced immune microenvironment remodeling in prostate cancer is correlated with recurrence-free survival and immune...

Latest updates on Remodeling market, a comprehensive study enumerating the latest price trends and pivotal drivers rendering a positive impact on the industry landscape. Further, the report is inclusive of the competitive terrain of this vertical in addition to the market share analysis and the contribution of the prominent contenders toward the overall industry.

High intensity of natural calamities particularly in China and Japan display high scope for disaster repair remodeling services. Extreme climatic variations majorly in North America and Europe show strong potential for services related to snow removal and property improvement. Requirement among the aged population to live in a peaceful house environment after their retirement will generate high investments in porch and gardens particularly in developed nations.

Residential remodeling market is expected to witness a CAGR of over 4% during the forecast period 2018 to 2024. Higher count of house gatherings along with rising consumer spending in developing economies will enhance the application market. Technological advancements providing better energy efficiency, enhanced designs, and highly durable materials along with need to increase the house security will drive the business growth globally. Increasing real estate prices in highly populated cities accompanied by the need for improved house space and design will support the services penetration.

Request Sample Copy of this Report @ https://www.theresearchprocess.com/request-sample/5377

Lower lending rates along with design innovations will primarily drive the global remodeling market growth. Increasing private infrastructural investments along with favorable government conditions offering tax concessions on home loans will enhance the services demand. Expanding tourism sector along with technological innovations particularly in Asia Pacific and Europe will boost the business advancement.

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North America remodeling market revenue was registered over 800 billion in 2017. Design innovations along with large disposable incomes & highest consumer spending are primary drivers for the expanding services demand in the region. Extreme climatic variations accompanied by frequent disasters support the market development in the region. Increasing necessity to improve the employee productivity and reduce energy expenses will propel the services adoption in the commercial segment.

The key industry players in the global remodeling market share include GAF Materials Corporation, JELD-WEN, Andersen Corporation, ABC Supply, Builders First Source, the Home Depot, Dow Building Solutions, Hanley Wood LLC, Ferguson Enterprises, and Fortune Brands Home & Security. Other prominent players in the industry are Lutron Electronics, Kohler Co., Masco Corporation, Move Inc., USG Corporation, National Gypsum Company, Oldcastle Building Products, Owens Corning, Pella Corporation, Ply Gem Industries Inc., ProBuild Inc., The Sherwin-Williams Company, and Mergers & acquisitions are among the key strategies adopted by the service providers to expand their product portfolio and gain market share. For instance, Norcraft companies was acquired by Fortune Brands Home and Security to expand their product portfolio in the residential segment.

Commercial remodeling is expected to account for over USD 2 trillion by 2024. Necessity to reduce the fixed costs particularly electricity expenses along with providing a better environment to work in corporate offices will surge the business expansion. Trend towards transforming the office into eco-friendly to improve employee health, working conditions along with the benefit of social marketing for the company.

Major Highlights from Table of contents are listed below for quick lookup into Remodeling Market report

Chapter 1. Methodology and Scope

Chapter 2. Executive Summary

Chapter 3. Remodeling Industry Insights

Chapter 4. Company Profiles

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Remodeling Market Trends, Companies, Driver, Segmentation, Forecast to 2024 - The Research Process

Brandessece Market Research recently added the Bioabsorbable Stent Market research report which offers a thorough study of the market scenario regarding the market size, share, demand, growth, trends, and forecast from 2020-2026. The report deals with the impact analysis of the COVID-19 pandemic. The COVID-19 pandemic has impacted exports, imports, demand and trends in the industry and is expected to have some economic impact on the market. The report offers a comprehensive analysis of the impact of the pandemic across the industry and provides insights into a post-COVID-19 market scenario.

List of TOP KEY PLAYERS in Bioabsorbable Stent Market Report are Abbott, BIOTRONIK SE & Co. KG, REVA Medical, Inc, Elixir Medical Corporation, Arterial Remodeling Technologies, others.

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Bioabsorbable Stent Industry 2020 Global Market research report studies the latest Bioabsorbable Stent industry aspects market size, share, trends, Opportunities and Strategies To Boost Growth, business overview, revenue, demand, marketplace expanding, technological innovations, recent development, and Bioabsorbable Stent industry scenario during the forecast period (2020-2025).

What are the key segments in the market?

Geographically, the global culture media market can be segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. Geographically, North America is expected to hold the largest share of the market, and it is also anticipated to continue this trend in the forecast period. Increased government initiatives for research, the invention of new technologies and advancements in cell culture applications, clinical studies on cancer, the presence of the world-class biotechnology & research institutes in the region are likely to propel the growth of the market in North America. Europe is projected to hold the second-largest share of the market. The growth of the market in this region can be attributed to the enormous investments and research activities in the biotechnology sectors, as well as the increasing trend in the adoption of new technologies. However, the Asia Pacific region is likely to hold the significant potential for the growth of the Bioabsorbable Stent market due to the increase in technological advances in the biotechnology and pharmaceutical sector, development of vaccines, and rising initiatives for in-vitro cultivations. Moreover, the emerging economies like China and India are expected to boost the growth of the market due to the growing capital and purchasing power of the countries in the Asia Pacific region. Latin America and the Middle East & Africa are increasing steadily in the market.

Highlights of the Report:

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Important Facts About Bioabsorbable Stent Market Report:

-The Bioabsorbable Stent industry report features different approaches and procedures endorsed by the market key players to make vital business decisions.-Bioabsorbable Stent market depicts some parameters such as production value, Bioabsorbable Stent marketing strategy analysis, Distributors/Traders and effect factors is also mentioned in this Bioabsorbable Stent research report.-This research report reveals Bioabsorbable Stent business overview, product overview, market share, supply chain analysis, demand and supply ratio and import/export details.

TABLE OF CONTENT

1 Report Overview

2 Global Growth Trends

3 Market Share by Key Players

4 Breakdown Data by Type and Application

5 United States

6 Europe

7 China

8 Japan

9 Southeast Asia

10 India

11 Central & South America

12 International Players Profiles

13 Market Forecast 2020-2025

14 Analysts Viewpoints/Conclusions

15 Appendix

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We publish market research reports & business insights produced by highly qualified and experienced industry analysts. Our research reports are available in a wide range of industry verticals including aviation, food & beverage, healthcare, ICT, Construction, Chemicals and lot more. Brand Essence Market Research report will be best fit for senior executives, business development managers, marketing managers, consultants, CEOs, CIOs, COOs, and Directors, governments, agencies, organizations and Ph.D. Students.

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Bioabsorbable Stent Market Size Share Analysis and System Production (2020-2026) | Abbott, BIOTRONIK SE & Co. KG, REVA Medical, Inc, Elixir...

Credit: Melissa Turtinen

If someone wants to build or add onto their home in Excelsior, they'll now face a far more rigorous process to get it approved.

A new ordinance the Excelsior City Council passed on a 3-2 vote Monday which goes into effect Oct. 1 gives Excelsior some of the strictest zoning regulations in the state.

Residents in Excelsior, a city with fewer than 3,000 people established in the 1850s on Lake Minnetonka, have been embroiled in a years-long debate over preserving the city's charm or allowing people to build their dream homes.

Neighborhoods in the small city include some homes that date back to the 1800s, and then on the same street are newly-built or remodeled homes that some argue just don't fit in with the area.

The Excelsior City Council determined that traditional zoning regulations haven't sufficiently preserved Excelsior's character and have failed to ensure that new homes are compatible with the neighborhood in which they're built, city documents state.

This led to the creation via the ordinance passed Monday of a Residential Review Process and Good Neighbor Guidelines, which require new builds, additions and remodels of single-family homes to be reviewed by the city's Planning Commission, architect and zoning administrator, as well as give residents who own property within 350 feet the opportunity to weigh in on the project prior to the city issuing a residential review permit.

Some small-scale projects that don't require a building permit are not subject to this process as they don't require a residential review permit, the ordinance notes.

Proponents of the ordinance, including the group Excelsior Forever, say it will ensure new houses fit in with their surroundings, preserving Excelsior's character and scale, which is why people chose to live there in the first place.

However, opponents, which include the group Unite Excelsior, have argued the guidelines are subjective and would negatively impact families, lower property values and discourage people from moving to the city.

Find a realtor using the Bring Me The News directory

The ordinance is not designed to regulate the architectural design of new construction and remodeling unless it affects mass, scale, bulk and/or orientation, documents say.

The residential review process ordinance wasn't the only zoning-related ordinance to pass on Monday. The City Council voted 5-0 to amend its ordinance related to landmark buildings within the city, allowing non-property owners to nominate single-family homes for landmark status so long as two people, including one resident, are part of the nomination.

If a landmark nomination is approved, the property owner has to get a special permit in order to do any major work to the exterior, the city's website says.

The change to the landmark ordinance came after a nomination was made by a renter, not a property owner, so it was rejected, the Sun Sailor reported.

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In Excelsior, neighbors now can have a say on whether you can expand your house - Bring Me The News

Two years after a Kennewick Taco Bell was torn down and rebuilt, a north Richland Taco Bellis gettinga makeover of its own.

Taco Bell,at1825 George Washington Way, istemporarily closed for an $800,000 makeover to bring it to the modern brand standards spelled out by Taco Bell owner Yum! Brands.

The updates include a down-to-the-studs interior remodel, electronic menu boards, more space in the kitchen and a new drive-thru, said John Arthur, president of Yakima Restaurants Inc., an Ohio-based company that owns and operates 32 Taco Bell franchises in Ohio andWashington.

Arthur manages the10 in Washington.

His identical twin brothermanagesthe Ohio ones.

The city of Richland issued permits on Aug. 21.

Taco Bell is one of two restaurants thatoperateinpadsat WashingtonPlaza,a Safeway-anchored strip mall at McMurray Street and George Washington Way. Sharis is the other. The complex was firstdeveloped in 1981.

Arthur said the exterior hasnt been significantly updated in the 30 years since itwasbuilt.Yum! Brandsnew standards for Taco Bell supplied the impetus to remodel, but he said Yakima Restaurants is going well beyond the minimum expected.

A bump out will add more space in the kitchen as well as storage space to better accommodate employees.

The restaurant is in the top 3 of the 10 Northwest locations for sales, he said.

It is also the mostaffected by the Covid-19 pandemic. Arthur attributes that to the loss of drive-by traffic since many Hanford site workers began working from home.

The restaurant will reopen in earlytomid-November as adrive-thru. Although restaurants can open at 25% capacity, Arthur wont reopen the dining room until it feels it is safe for employees.

About a third of the Richland employees are posted to the companys Road 68 location in Pasco. The remaining workers were laid off.

Arthur plans to remodel four Yakima-area Taco Bell locations in the nextone to twoyears.

Baxter Construction is the general contractor.

Read more:
Richland Taco Bell gets makeover, more square feet - tricitiesbusinessnews.com

Don Magruder| For the Daily Commercial

Recently, there was a controversial shooting in Georgia. One of the justifications pushed for this attack was that the victim was caught on video snooping around a construction job site in a neighborhood. This justification holds no merit because an unwanted visitor snooping around a construction job site is commonplace and a daily occurrence.

For that reason, builders and homeowners should take tangible and passive measures to guard and protect their construction job site to prevent theft and vandals without shooting people.

The other aspect motivating unwanted job site visits is the current price of building materials. With lumber, plywood, and other construction materials at record-high prices, people who have projects of their own would love to stop at your project to find building materials.

I thought it was trash, is the excuse most thieves use when caught stealing things from a job site. Have a firm policy for all contractors and subcontractors working on your job site nothing leaves, including the trash, without your permission.

The first thing a builder or homeowner should do after putting up the permit box is post No Trespassing signs throughout the job site. Prominently posted signs with strong language about pressing charges for trespassing will discourage honest, nosy people from walking onto your job site. Do not be stingy with posting them make the signs prominent and plentiful.

When the construction process starts, guard and protect all building materials. Thieves understand pricing better than you, and currently the prices of many building material items are at record levels. During the foundation and framing stages of your construction project, do not ship out more material in a day that can be nailed down or locked up.

Unemployment is high, building material prices are at record levels, and many items are hard to get with extended lead times. This is not the time to have building materials stolen only have on the job site what can be installed or used that day.

Prioritize the completion of the outside shell of your new home or remodel project quickly so that windows and doors can be locked. While this will not keep a hardened criminal out, it will generally keep most teenagers, vandals, and wild critters out of your project. Do not make it easy for just anyone to walk onto your project.

Modern motion sensor lights and cameras are very affordable and provide a real deterrent if the homeowner or builder advises would be trespassers that the premises are under surveillance. Some people have a misconception when it comes to using a surveillance system.

Security cameras and surveillance systems are not designed to simply catch people doing bad things on your property they are also installed to deter them from making the attempt. In my view, installing a security camera and surveillance system without prominently posting a warning sign is a waste.

Do not store expensive tools or materials inside your project. Also, if you are doing a remodeling project while you are living in the home, lock up and secure all your valuables. Labor is very tight in the construction industry and many companies have been forced to hire employees and subcontractors with blemished backgrounds. While most contractors or subcontractors are extremely honest, it only takes one dishonest person. Until work is completed on the project, secure all your valuable items.

With the price of plywood currently over $20 per sheet and 2 x 4 studs nearing $6 per piece, it only takes a few pieces of each to lose $100. Guarding and protecting your construction job site can save real money. However, please do so peacefully do not be alarmed when you find out that your neighbor wandered onto your job site simply being nosy while it is under construction.

Don Magruder is the CEO of RoMac Building Supply and host of Around the House, which can be seen at AroundtheHouse.TV.

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Guard and protect your job site - Daily Commercial